《生命科学》 2021, 33(1): 104-110

母乳成分改变影响子代脂肪肝发生的研究进展

郭　麒^1,2 , 许珂铨^1,2 , 戴永国^1,2 , 汪　晖^1,2 , 郭　喻^1,2,*

¹武汉大学基础医学院药理学系，武汉 430071 ²发育源性疾病湖北省重点实验室，武汉 430071

摘　要：

近年来，哺乳期不良母体因素导致的乳汁成分改变对个体生长发育以及代谢性疾病发生的影响受到越来越多的关注。乳汁作为哺乳动物出生早期唯一的营养来源，其成分的改变可能会影响子代整体代谢稳态，进而导致子代代谢性疾病的发生。大量的动物实验表明，哺乳期不良母体因素可改变乳汁成分，同

时导致哺乳期子代脂肪肝，并且可持续至成年。该文将就哺乳期不良母体因素导致乳汁成分改变对子代脂肪肝发生的影响及其可能机制进行综述，旨在更新哺乳期不良母体因素对子代肝脏脂代谢功能影响的认识，并为产妇的健康饮食提供参考。

通讯作者：郭　喻 , Email:guoy@whu.edu.cn

Influence of changes in breast milk composition on fatty liver of offspring: an update

GUO Qi^1,2 , XU Ke-Quan^1,2 , DAI Yong-Guo^1,2 , WANG Hui^1,2 , GUO Yu^1,2,*

¹Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China ²Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China

Abstract:

In recent years, more and more attention has been paid to the influence of changes in breast milk composition, which may be caused by adverse maternal factors during lactation, on the individual growth and development and the occurrence of metabolic diseases in offspring. Breast milk is the only source of nutrients in the early life of mammals, and changes in its composition may affect the homeostasis of integral metabolism in offspring, and consequently lead to metabolic diseases. A large number of animal experiments have shown that adverse maternal status during lactation can change the composition of breast milk, and simultaneously lead to fatty liver in suckling infants, and even continue to adulthood. This review focused on effects of changes in breast milk composition on fatty liver in offspring and the possible underlying mechanisms. This review may help us to update the understanding how adverse maternal factors affect lipid metabolism function of the offspring, and to provide a reference for the maternal diet during lactation.

Communication Author：GUO Yu , Email:guoy@whu.edu.cn