《生命科学》 2021, 33(1): 87-94

TRIM29在肿瘤中的研究进展

刘晨茜 , 田秋明 , 盛德乔^*

三峡大学医学院，肿瘤微环境与免疫治疗湖北省重点实验室，宜昌 443002

摘　要：

TRIM29蛋白属于TRIM蛋白家族，是一种E3泛素连接酶，它在肿瘤的增殖、侵袭转移、耐药及肿瘤免疫中都具有十分重要的作用，且其功能具有细胞和组织特异性。TRIM29蛋白可通过与p53的相互作用促进肿瘤细胞的增殖；通过促进肿瘤细胞上皮-间质转化、激活经典的Wnt信号通路等增强肿瘤细胞的侵袭转移能力。高表达的TRIM29可与DNA修复因子RNF8相互作用促进DNA损伤的修复，也可激活PI3K/AKT信号通路促进P-糖蛋白的表达，从而增强肿瘤细胞对放化疗的耐受性。另外，TRIM29还可调控NK细胞及肺泡巨噬细胞的功能。明确TRIM29在不同肿瘤中的表达水平与功能，可为肿瘤的诊断与治疗提供新的

思路。

通讯作者：盛德乔 , Email:shengdq@ctgu.edu.cn

Research progress of TRIM29 in cancer

LIU Chen-Xi , TIAN Qiu-Ming , SHENG De-Qiao^*

Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Medical College of China Three Gorges University, Yichang 443002, China

Abstract:

TRIM29, as an E3 ubiquitin ligase, belongs to the TRIM protein family. It plays an important role in tumor proliferation, invasion and metastasis, drug resistance and tumor immunity, and its function is cell- and tissue-specific. TRIM29 protein can promote the proliferation of tumor cells through the interaction with p53, and enhances invasion and metastasis of tumor cells by promoting epithelial mesenchymal transition and activating the classic Wnt signaling pathway. Overexpression of TRIM29 can interact with RNF8 to promote the repair of DNA damage, and activate PI3K/AKT signaling pathway to promote the expression of P-glycoprotein, thus enhancing the tolerance of tumor cells to radiotherapy and chemotherapy. In addition, TRIM29 can also regulate the function of NK cells and alveolar macrophages. To clarify the expression level and function of TRIM29 in different tumors may provide a new idea for the diagnosis and treatment of tumors.

Communication Author：SHENG De-Qiao , Email:shengdq@ctgu.edu.cn