《生命科学》 2021, 33(1): 68-76

Wnt信号通路在突触可塑性及学习记忆中的作用

项　鹏 , 郭　柳 , 曾　燕 , 陈雨珊^*

武汉科技大学医学院，脑科学先进技术研究院，武汉 430065

摘　要：

Wnt信号通路与大脑发育和中枢神经系统成熟密切相关，参与神经突触调节和重塑，在突触可塑性和学习记忆中有重要作用。该文综述了Wnt信号在突触结构与功能中的作用，Wnt信号途径与突触结构和神经功能的建立与维持的关系，以及Wnt信号在学习记忆相关的突触重塑与稳定中的重要作用。对Wnt信号通路的深入了解有助于理解学习记忆的结构机制，为记忆障碍相关的疾病提供新型治疗策略。

通讯作者：陈雨珊 , Email:yschen0101@126.com

The role of Wnt signaling in synaptic plasticity and learning and memory

XIANG Peng , GUO Liu , ZENG Yan , CHEN Yu-Shan^*

Brain Science and Advanced Technology Institute, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China

Abstract:

Wnt signaling pathway has been shown to be closely related to brain development and the maturation of central nervous system. It is involved in the synaptic regulation and remodeling, which plays a critical role in

synaptic plasticity and learning memory. This article  reviews the role of Wnt signaling in synaptic structure and function, the relationship between Wnt signaling and establishment and maintain of synaptic structure and

neurological function, and its important role in synaptic remodeling and stabilization of learning and memory. Deep insight into Wnt signaling pathway helps us to understand the structural mechanism of learning memory, providing new strategies for the therapy of memory disorders.

Communication Author：CHEN Yu-Shan , Email:yschen0101@126.com