《生命科学》 2021, 33(1): 53-60

GPER在脑组织中作用及机制的研究进展

冯　钰 , 卞学鹏 , 田　旭 , 商庆慧 , 娄淑杰^*

上海体育学院运动科学学院，上海 200438

摘　要：

近年来，G蛋白偶联雌激素受体(G protein-coupled estrogen receptor, GPER)受到了广泛关注，作为一种雌激素膜受体，GPER在不同组织中都有重要作用。在脑组织中，GPER通过调控多条信号通路，起到了保护神经、增强学习记忆能力、调控情绪等作用。因此，该文主要就GPER在脑组织中调控的信号通路及其作用进行综述，进一步理解GPER对脑组织结构和功能的影响。

通讯作者：娄淑杰 , Email:shujielou319@163.com

The functions and mechanisms of GPER in brain

FENG Yu , BIAN Xue-Peng , TIAN Xu , SHANG Qing-Hui , LOU Shu-Jie^*

School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China

Abstract:

In recent years, the G protein-coupled estrogen receptor (GPER) has received worldwide attention. GPER plays an important role in different tissues as an estrogen membrane receptor. In the brain, GPER mediates neuroprotection, enhances learning and memory ability, and regulates emotions by activating multiple signal

pathways. Therefore, this paper reviewed the main signaling pathways and functions regulated by GPER in the brain tissue, in order to further understand the influence of GPER on the structure and function of brain.

Communication Author：LOU Shu-Jie , Email:shujielou319@163.com