《生命科学》 2021, 33(1): 36-43

噬菌体与细菌相互作用的分子机制研究进展

谢翰楠¹ , 安庆宇¹ , 刘　畅^1,* , 郭晓奎² , 陈　倩^1,*

¹上海交通大学医学院免疫学与微生物学系，上海 200025 ²国家热带病研究中心全球健康学院

摘　要：

噬菌体与细菌是自然界中存在最广泛的两类微生物，两者在群体水平、个体水平以及分子水平上均存在复杂的相互作用关系。细菌能够影响溶原性噬菌体的溶原-裂解决策，而被噬菌体感染的细菌基因表达谱也会受到噬菌体影响，使宿主菌的代谢、应激、抵抗力、毒性等多种性状发生改变。现从细菌和噬菌体两者的角度，分别综述细菌抵抗噬菌体感染以及噬菌体对具有抗性的细菌进行再感染的机制。

通讯作者：刘　畅 , Email:tiantianlc@sjtu.edu.cn 陈　倩 , Email:Xitiruo@sjtu.edu.cn

Research progress in the interactions between bacteriophages and bacteria at the molecular level

XIE Han-Nan¹ , AN Qing-Yu¹ , LIU Chang^1,* , GUO Xiao-Kui² , CHEN Qian^1,*

¹Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China ²School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai 200025, China

Abstract:

Bacteriophages and bacteria are the most numerous biological entities among the microbiota in nature. There are complex interactions between them at the community level, individual level and molecular level. The lysis-lysogeny decisions of lysogenic phages can be affected by their bacterial hosts. Meanwhile, gene expression profiles of the infected bacteria can be modulated by bacteriophages, which could further influence multiple bacterial characteristics including metabolism, stress,  resistance, toxicity, etc. In this review, mechanisms of the

interactions between bacteriophages and bacteria at the molecular level were summarized respectively, including

bacterial anti-phage defense systems and reinfection mechanisms of bacteriophages.

Communication Author：LIU Chang , Email:tiantianlc@sjtu.edu.cn CHEN Qian , Email:Xitiruo@sjtu.edu.cn