《生命科学》 2021, 33(1): 7-14

外周炎症对血脑屏障功能的影响及其机制研究进展

黄晓雯^1,2 , 畅君雷^1,*

¹中国科学院深圳先进技术研究院生物医药与技术研究所，深圳 518055 ²中国科学院大学深圳先进技术学院，深圳 518055

摘　要：

血脑屏障是将中枢神经系统与外周循环中的炎症介质和效应性免疫细胞分隔开的重要生理屏障，由脑血管内皮细胞和周围的血管周细胞、胞外基质膜以及星形胶质细胞等构成，对维持脑微环境和正常生理功能至关重要。临床和实验研究表明，外周炎症与血脑屏障破坏有关，炎症可以通过多种途径影响血脑屏障的正常功能，导致中枢神经系统疾病的发生发展。因此，研究外周炎症如何影响血脑屏障的正常功能，可以为保护血脑屏障免受外周炎症破坏提供重要依据。现综述外周炎症对血脑屏障功能的作用及其机制，并分析其与最近的研究热点CAR-T细胞疗法和新型冠状病毒肺炎COVID-19的相关性。

通讯作者：畅君雷 , Email:jl.chang@siat.ac.cn

Research progress of the effect and mechanism of peripheral inflammation on blood-brain barrier function

HUANG Xiao-Wen^1,2 , CHANG Jun-Lei^1,*

¹Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China ²Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen 518055, China

Abstract:

The blood-brain barrier (BBB) is an important physiological barrier separating central nervous system (CNS) from inflammatory mediators and effector immune cells in the peripheral circulation. BBB is composed of cerebrovascular endothelial cells, surrounding pericytes, extracellular matrix membrane as well as astrocytes. BBB is crucial for the microenvironment homeostasis and normal function of the brain. Both clinical and experimental studies have shown that peripheral inflammation is associated with BBB disruption, and affects the BBB function through various ways, leading to the occurrence and development of CNS diseases. Therefore, elucidation of the mechanisms underlying BBB disruption caused by peripheral inflammation will provide an important basis for the protection of BBB from inflammation. In this review, we comprehensively summarized the research progresses on the effect of peripheral inflammation on BBB function and the underlying mechanisms, as well as the relevance to

CAR-T therapy and COVID-19.

Communication Author：CHANG Jun-Lei , Email:jl.chang@siat.ac.cn