《生命科学》 2020, 32(12): 1401-1407

运动对神经肌肉接头老龄化的调节作用

蓝永生¹ , 于　淼² , 曹让娟^3,*

¹长春师范大学体育学院，长春 130032 ²东北师范大学体育学院，长春 130024 ³吉林大学中日联谊医院，长春 130033

摘　要：

神经肌肉接头(neuromuscular junction, NMJ)是连接运动神经元和肌纤维的胆碱能突触，是神经元控制骨骼肌运动的结构基础。衰老过程伴随着神经肌肉接头的退行性改变，而运动能改善神经肌肉接头的结构和功能。现对神经肌肉接头老龄化特征、运动调节神经肌肉接头老龄化的作用及分子机制进行综述，希望对进一步研究和改善神经肌肉接头老龄化提供参考。

通讯作者：曹让娟 , Email:caorj@jlu.edu.cn

Effects of exercise on NMJ improvement in aging

LAN Yong-Sheng¹ , YU Miao² , CAO Rang-Juan^3,*

¹College of Physical Education, Changchun Normal University, Changchun 130032, China ²College of Physical Education, Northeast Normal University, Changchun 130024, China ³China-Japan Union Hospital of Jilin University, Changchun 130033, China

Abstract:

Neuromuscular junction (NMJ) is a cholinergic synapse formed between motor neurons and skeletal muscle fibers, which is the structural basis for neurons to control muscle contraction. NMJ undergoes degenerative changes with aging. Exercising can improve the structure and function of aged NMJ. In this paper, we reviewed the characteristics of aged NMJ, the effects of exercise on its improvement, as well as the underlying molecular mechanism. These are of great significance for further improvement of neuromuscular junction in aging.

Communication Author：CAO Rang-Juan , Email:caorj@jlu.edu.cn