《生命科学》 2020, 32(12): 1391-1400

2型糖尿病作为危险因素诱发胰腺癌的相关机制研究进展

许峰晟¹ , 封　凡¹ , 杜　飞² , 张洪江^2,* , 杨康鹃¹

¹延边大学医学院，延吉 133002 ²延边大学附属医院，延吉 133002

摘　要：

2型糖尿病(type 2 diabetes mellitus, T2DM)是当今威胁人类健康的严重疾病之一。研究发现，病程≥2年T2DM患者的胰腺癌(pancreatic cancer, PC)发病的风险率为1.64 (1.52~1.78)。T2DM与PC关系密切，不少学者认为T2DM是PC发病的危险因素。T2DM和PC皆为复杂性疾病，在各自的病情发生发展过程中涉及许多共同的危险因素，如肥胖、高脂高热量饮食、吸烟等。同时，以上某些危险因素在T2DM患者罹患PC的过程中起促进作用。另外，在发生机制方面，T2DM可通过Wnt/β-catenin信号通路、胰岛素/胰岛素样生长因子1受体信号通路和PI3K/AKT信号通路诱导PC发生。该文对近年来T2DM诱发PC发生发展的相关性及其机制方面的研究进展进行综述。

通讯作者：张洪江 , Email:15526770420@163.com

Advances on the related mechanism of type 2 diabetes as a risk factor inducing pancreatic cancer

XU Feng-Sheng¹ , FENG Fan¹ , DU Fei² , ZHANG Hong-Jiang^2,* , YANG Kang-Juan¹

¹College of Medicine, Yanbian University, Yanji 133002, China ²Affiliated Hospital of Yanbian University, Yanji 133002, China

Abstract:

Type 2 diabetes mellitus (T2DM) is one of the serious diseases that threaten human health. It was found that the risk of developing pancreatic cancer (PC) for patients with T2DM two or more years was 1.64 (1.52~1.78). T2DM is closely related to PC, and many scholars believe that T2DM is a risk factor of PC. Both T2DM and PC are complex diseases and their occurrence and development involve lots of common risk factors, such as obesity, high-fat and high-calorie diets and smoking. At the same time, some of the above risk factors were found to play a promoting role in the development of PC in T2DM patients. In addition, it was found that PC can be induced through the Wnt/β-catenin signaling pathway, the insulin/insulin-like growth factor 1 receptor signaling pathway and PI3K/AKT signaling pathway in T2DM patients. This paper reviews the research progress of the role of T2DM in the occurrence and development of PC and related mechanism in recent years.

Communication Author：ZHANG Hong-Jiang , Email:15526770420@163.com