《生命科学》 2020, 32(12): 1346-1356

阿尔兹海默病及其诊断中环状RNA的研究进展

彭伟嘉¹ , 鲁俊锋¹ , 朱泽宇¹ , 杨　扬¹ , 皮荣标^2,3,*

¹中山大学药学院药理毒理实验室，广州 510006 ²中山大学医学院，广州 510006 ³广东省<中山大学-香港理工大学>抗失智创新药物联合实验室，广州 510006

摘　要：

阿尔兹海默病(Alzheimer’s disease, AD)是最常见的神经退行性疾病，临床主要表现为进行性认知功能减退。环状RNA (circular RNA, circRNA)是一类内源性的非编码环状RNA分子，其特征在于以共价键形成封闭环状结构，它具有结构稳定、序列保守、功能多样和组织细胞特异性。CircRNA已证实能通过小RNA (microRNA, miRNA)海绵作用影响神经元发生与损伤、Aβ沉积、神经炎症、自噬与突触功能，在AD发生与发展中发挥重要作用。目前研究发现，AD中差异表达的circRNA有可能为AD提供潜在的治疗靶点，并作为AD的疾病风险和进展标志记物或药物疗效评价标记物。

通讯作者：皮荣标 , Email:pirb@mail.sysu.edu.cn

Research progress of circular RNA in Alzheimer’s disease and diagnosis

PENG Wei-Jia¹ , LU Jun-Feng¹ , ZHU Ze-Yu¹ , YANG Yang¹ , PI Rong-Biao^2,3,*

¹Department of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China ²School of Medicine, Sun Yat-Sen University, Guangzhou 510006, China ³International Joint Laboratory (SYSU-PolyU HK) of Novel Anti-Dementia Drugs of Guangdong, Guangzhou 510006, China

Abstract:

Alzheimer’s disease (AD) is the most common neurodegenerative disease, and its clinical manifestations are mainly progressive cognitive function degeneration. Circular RNA (circRNA) is an endogenous non-coding RNA, characterized by a covalent bond to form a closed circular structure. It has stable structure, conservative sequence, diverse functions and tissue-cell specificity. CircRNA has been proved to affect neurongenesis and damage, Aβ deposition, neuroinflammation, autophagy and synaptic function through microRNA (miRNA) sponge, and plays an important role in AD occurrence and development. Current studies found that circRNA differentially expressed in AD may provide a potential therapeutic target for AD, and serve as a marker of disease risk and progression of AD, or a marker for evaluating drug efficacy of AD.

Communication Author：PI Rong-Biao , Email:pirb@mail.sysu.edu.cn