《生命科学》 2020, 32(12): 1331-1337

胆囊发育调控机制的研究进展

王夏爽 , 吴　迪 , 吴芬芳^*

北京中医药大学深圳医院，深圳 518000

摘　要：

胆囊是肝外胆道系统中负责胆汁储存、浓缩及外排的一个囊状结构，其发育或功能的异常可引发硬化性胆管炎、胆道闭锁等疾病，致使胆汁过度淤积于肝脏，进而造成肝损伤。深入了解胆囊的发育机制，对基础生物学研究、肝外胆管疾病的病理病因解释、相关治疗策略的制定及改良均有重大价值。然而，目前胆囊发育的相关研究凤毛麟角，更鲜有综述报道。该综述围绕胚胎发育早期肝外胆管的形成过程，系统地阐述参与胆囊发育调控的关键信号通路及相关分子，为发育生物学研究、胆囊的病例解析以及药物研发提供系统性的指引与参考。

通讯作者：吴芬芳 , Email:wufenfang19@126.com

Research progress on regulation of gallbladder development

WANG Xia-Shuang , WU Di , WU Fen-Fang^*

Shenzhen Hospital of Beijing University of Chinese Medicine, Shenzhen 518000, China

Abstract:

Gallbladder is a cystic structure responsible for the storage, concentration and excretion of bile in the extra-hepatic biliary system. The abnormal development or dysfunction of gallbladder can lead to sclerosing cholangitis, biliary atresia and other diseases, resulting in excessive cholestasis and liver injury. A thorough understanding of gallbladder development plays an important role in foundational research, pathology of extrahepatic biliary diseases and formulation and improvement of related therapeutic strategies, however, few researches and reviews on gallbladder development have been reported. This review focuses on the formation of extra-hepatic bile duct in early embryonic development, elaborates the key signals and related molecules involved in gallbladder development, and provides a systematic guidance and reference for developmental research, pathological analysis and drug development.

Communication Author：WU Fen-Fang , Email:wufenfang19@126.com