《生命科学》 2020, 32(12): 1315-1321

CD36在非酒精性脂肪性肝病发生发展中的作用

林　晨 , 李晓晓 , 曾俊豪 , 刘朝奇^*

三峡大学肿瘤微环境与免疫治疗湖北省重点实验室，宜昌 443002

摘　要：

非酒精性脂肪性肝病的发病率快速上升且趋于年轻化，已经成为危害人类公共卫生健康的重大问题，其相关分子机制和分子靶点成为研究热点。CD36属于清道夫受体，参与脂肪酸的跨膜转运过程，对肝脏的代谢至关重要。其中，CD36可介导代谢失调的炎症反应进而促进肝脏疾病的发生发展。该文综述CD36的功能与其在肝脏代谢性疾病进展中的作用及其相关机制。

通讯作者：刘朝奇 , Email:ctgulcq@163.com

Role of CD36 in the NAFLD progression

LIN Chen , LI Xiao-Xiao , ZENG Jun-Hao , LIU Chao-Qi^*

Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang 443002, China

Abstract:

The incidence of nonalcoholic fatty liver disease is rising rapidly and tends to be younger, which has become a major problem endangering human public health, and its related molecular mechanism and molecular targets have become a research hotspot. CD36 belongs to scavenger receptor, which participates in the transmembrane transport of fatty acids and is very important for liver metabolism. Further, CD36 can mediate the inflammatory response of metabolic disorders and promote the occurrence and development of liver disease. Therefore, this article reviews the function of CD36 and its role in the progression of liver metabolic diseases and its related mechanism.

Communication Author：LIU Chao-Qi , Email:ctgulcq@163.com