《生命科学》 2020, 32(11): 1237-1242

布鲁氏菌病关节炎的致病机制研究进展

王　鑫 , 丁家波^*

中国兽医药品监察所国家/OIE布鲁氏菌病参考实验室，北京 102600

摘　要：

布鲁氏菌病(布病)是由布鲁氏菌感染引起的一种人畜共患传染病。动物与人感染布鲁氏菌都能表现累及关节相关的症状，即布病关节炎。典型的动物病理模型表明，布鲁氏菌关节炎发病时关节腔周围组织有大量中性粒细胞、单核细胞和破骨细胞的浸润并伴有明显的骨破坏。除了布鲁氏菌对骨关节细胞的直接作用外，布鲁氏菌和骨组织细胞、免疫细胞还通过细胞因子产生级联互作效应，吸引中性粒细胞、单核细胞迁移并促进破骨细胞生成，导致骨组织破坏。然而，人与动物布鲁氏菌病关节炎发病机制、感染过程中多细胞间的互作效应等仍不甚清楚，有待探索。

通讯作者：丁家波 , Email:dingjiabo@126.cm

Research progress in pathogenesis of brucellosis arthritis

WANG Xin , DING Jia-Bo^*

National/OIE Reference Laboratory for Animal Brucellosis, China Institute of Veterinary Drug Control, Beijing 102600, China

Abstract:

Brucellosis (brucellosis) is a zoonotic infectious disease caused by Brucella. Brucella infection in both animals and human can show symptoms of joint involvement, i.e. brucellosis arthritis. Typical animal pathological models showed that there were a large number of neutrophils, monocytes and osteoclasts in periarticular tissues of Brucella arthritis, accompanied by obvious bone destruction. In addition to the direct effect of Brucella on
osteoarticular cells, Brucella, bone tissue cells and immune cells also produce cascade interaction effects through cytokines to attracte neutrophils and monocytes to migrate and promote osteoclast formation, thus leading to bone destruction. However, the pathogenesis of human and animal brucellosis arthritis, and the multicellular interaction effect in the process of infection are still unclear and need to be explored.

Communication Author：DING Jia-Bo , Email:dingjiabo@126.cm