《生命科学》 2020, 32(11): 1198-1204

隐花色素调节cAMP-PKA信号通路及其与疾病关系的研究现状

郑　伟 , 姚鹏程 , 周志强 , 徐　蕾^*

(皖南医学院活性生物大分子研究安徽省重点实验室，芜湖 241002)

摘　要：

隐花色素(cryptochrome, CRY) 属于隐花色素/ 光裂解酶蛋白家族(CPF)，与光裂解酶具有高度同源性。与光裂解酶不同的是，CRY 在哺乳动物中主要起到调节生物钟的作用，并不具备修复紫外损伤DNA 的功能。除了参与生物节律的调节外，CRY 还可以调节cAMP-PKA ( 环磷酸腺苷- 蛋白激酶A) 信号通路，从而影响多种人类疾病，如炎症、肿瘤、代谢性疾病以及睡眠障碍性疾病的发展。近来，随着研究的深入，CRY 在多种疾病中发挥的作用也受到更多人的关注。该文着重介绍CRY 调节cAMP-PKA 信号通路的作用机制，及其与肿瘤、糖代谢紊乱、炎症以及睡眠障碍等疾病的发生发展的关系。

通讯作者：徐　蕾 , Email:hsuley@ustc.edu

Research status of cryptochrome regulating the cAMP-PKA signaling pathway and its relationship to diseases

ZHENG Wei , YAO Peng-Cheng , ZHOU Zhi-Qiang , XU Lei^*

(Anhui Province Key Laboratory of Active Biological Macro-molecules, Wannan Medical College, Wuhu 241002, China)

Abstract:

Cryptochromes (CRY) belong to the cryptochrome/photolyase family (CPF), which have a high degree of homology with photolyases. In mammals, however, CRY mainly regulates the circadian clock, but cannot repair UV-damaged DNA. In addition, CRY can regulate the cAMP-PKA (cyclic adenosine monophosphate-protein kinase A) signaling pathway, and thus affect the progress of many human diseases, including inflammation, cancer, metabolic diseases and sleep disorders. Recently, the role of CRY in various diseases has attracted more attention. This review focuses on the mechanism of CRY regulating the cAMP-PKA signaling pathway, and its relationship to the occurrence and development of diseases such as cancer, glucose metabolism disorder, inflammation and sleep disorders.

Communication Author：XU Lei , Email:hsuley@ustc.edu