《生命科学》 2020, 32(11): 1159-1175

FOXP3⁺调节性T细胞与人体传染性疾病

严　妍 , 那迪娜•帕尔哈提 , 车千纪 , 罗　菁 , 刘鑫男 , 李　斌^*

(上海交通大学医学院，上海市免疫学研究所，上海 200025)

摘　要：

FOXP3⁺调节性T细胞(FOXP3⁺Treg)是一类能够发挥免疫抑制等调节作用的T细胞亚群，是维持正常人体免疫稳态的关键。近期越来越多的研究揭示了FOXP3⁺Treg细胞在各类临床疾病的病理过程中所发挥的作用及其分子机制，这为研发针对FOXP⁺Treg细胞的免疫疗法奠定了基础。该综述将首先对FOXP3⁺Treg细胞的发育及其基本功能进行概述，并重点阐述近年来有关Treg细胞在传染性疾病中的生理功能、调控机制及针对FOXP3⁺Treg细胞治疗的研究新进展，并提出相应展望。

通讯作者：李　斌 , Email:binli@shsmu.edu.cn

FOXP3⁺ regulatory T cell in human infectious diseases

YAN Yan , NADINA Paerhati , CHE Qian-Ji , LUO Jing , LIU Xin-Nan , LI Bin^*

(Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China)

Abstract:

FOXP3⁺ regulatory T cell (FOXP3⁺Treg) is a subgroup of T lymphocytes with immunosuppressive effects and plays an essential role in the maintenance of human immune homeostasis. Recently, more and more researches revealed the role of FOXP3⁺Treg in the pathogenic processes of human clinical diseases and its mechanism, which lays the foundation for the immune therapies targeting FOXP3⁺Treg. In this review, the development and function of FOXP3⁺Treg will be summarized at first. Then, we will focus on the recent advances in physiological functions and regulatory mechanisms of FOXP3⁺Treg in major infectious diseases as well as the therapeutic strategies, and look forward to the future development.

Communication Author：LI Bin , Email:binli@shsmu.edu.cn