《生命科学》 2020, 32(10): 1135-1141

环境因素对炎症性肠病易感性的影响

李玉龙¹ , 邓　勖¹ , 杨志强² , 党　琳^1,*

¹陕西中医药大学基础医学院，咸阳 712046 ²山东省饲料质量检验所，济南 250000

摘　要：

炎症性肠病(inflammatory bowel disease, IBD)是一种病因尚未阐明的肠道异质性疾病，而炎症性疾病的治疗策略在很大程度上需依据其发病机理进行制定。除遗传因素外，肠道微生物、营养因素、药物等环境因子可通过改变肠道微环境影响肠道黏膜免疫稳态和炎症反应活性，进而影响炎症性肠病的易感性。该文就环境因素对炎症性肠病易感性的影响及基于环境因素作用可选的潜在治疗措施进行阐述。

通讯作者：党　琳 , Email:dlinmen@163.com

Effects of environmental factors on the susceptibility of inflammatory bowel disease

LI Yu-Long¹ , DENG Xu¹ , YANG Zhi-Qiang² , DANG Lin^1,*

¹College of Basic Medical Science, Shaanxi University of Chinese Medicine, Xianyang 712046, China ²Shandong Feed Quality Inspection Institute, Jinan 250000, China

Abstract:

Inflammatory bowel disease (IBD) is a heterogeneous group of intestinal diseases, the pathogenesis of which has not been clarified. Whereas, the formulation of IBD cure strategies are based mainly on IBD pathogenesis. In addition to genetic factors, environmental factors, including intestinal bacteria, nutritional factors, and medicines, could also affect the immune homeostasis of intestinal mucosal immune system by modulating the physicochemical properties of intestinal microenvironment. And so, environmental factors could effectively alter the individual’s susceptibility to IBD. In this review, we summarize and discuss the effects of environmental factors on IBD, as well as the potential therapies to reverse or significantly alleviate IBD.

Communication Author：DANG Lin , Email:dlinmen@163.com