《生命科学》 2020, 32(10): 1088-1098

锚定蛋白AKAP79/150介导心血管功能调控的研究进展

刘　霜¹ , 徐召霞¹ , 石丽君^1,2,*

¹北京体育大学运动生理学教研室，北京 100084 ²北京体育大学运动与体质健康教育部重点实验室，北京 100084

摘　要：

心血管疾病是全球范围成人死亡的首要原因，严重威胁着人类健康。A型激酶锚定蛋白(A-kinase anchoring proteins, AKAPs)是细胞内普遍存在的一类支架蛋白，它们通过与细胞内多种激酶相互结合，确保激酶的时空准确性，调节细胞内信号转导，参与调节人体多项生理功能。作为一种多价锚定蛋白，A型激酶锚定蛋白79/150 (A-kinase anchoring protein 79/150, AKAP79/150)可以调控多种信号分子的时空协同性，使信号得以准确转导，参与调节多项心血管生理病理过程。现就AKAP79/150介导的心血管调控机制及研究进展进行综述。

通讯作者：石丽君 , Email:shilj@bsu.edu.cn

Advances in research on anchor protein AKAP79/150-mediated regulation of cardiovascular function

LIU Shuang¹ , XU Zhao-Xia¹ , SHI Li-Jun^1,2,*

¹Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China ²Key Laboratory of Sports and Physical Health Ministry of Education, Beijing Sport University, Beijing 100084, C

Abstract:

Cardiovascular disease is the leading cause of adult death worldwide, and it is a serious threat to human health. A-kinase anchoring proteins (AKAPs) are a type of scaffold proteins that are ubiquitous in cells. They can bind to various kinases in cells to ensure the temporal and spatial accuracy of kinases, regulating intracellular signal transduction, involving in regulating many physiological functions of the human body. As a multivalent anchor protein, AKAP79/150 modulates the spatiotemporal coordination of multiple signal transduction molecules, enabling accurate signal transduction, participating in the regulation of cardiovascular physiological and pathological processes. Therefore, this article reviews the mechanism and advances in research on AKAP79/150-mediated cardiovascular regulation.

Communication Author：SHI Li-Jun , Email:shilj@bsu.edu.cn