《生命科学》 2020, 32(10): 1058-1065

SOX9在肿瘤发生中的作用及调控机制的研究进展

申雅洁^1,2 , 江代纪² , 彭子京² , 任逸倬² , 齐以涛^1,* , 马　皎^2,*

¹陕西师范大学生命科学学院细胞生物学系，西安 710119 ²上海交通大学医学院生化及分子细胞生物学系，上海 200025

摘　要：

SOX9是SOX基因家族的重要成员之一，已证实其异常表达与肿瘤的发生密切相关。当今，肿瘤的治疗已从传统的手术、放疗、化疗向针对与肿瘤发生密切相关的病态基因的精准靶向治疗改变，因此寻找新的药物靶点至关重要。SOX9调控细胞内多个信号通路如Wnt和Notch等以及靶基因的表达，影响肿瘤的发生。现就SOX9的结构、生理功能、对信号通路和肿瘤的影响进行综述，并展望未来SOX9的研究方向及临床应用前景。

通讯作者：齐以涛 , Email:qiyitao@snnu.edu.cn 马　皎 , Email:drjiaoma@shsmu.edu.cn

The advance in the role of SOX9 in tumorigenesis

SHEN Ya-Jie^1,2 , JIANG Dai-Ji² , PENG Zi-Jing² , REN Yi-Zhuo² , QI Yi-Tao^1,* , MA Jiao^2,*

¹Department of Cell Biology, School of Life Science, Shaanxi Normal University, Xi’an 710062, China ²Department of Biochemistry and Molecular Cell Biology, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China

Abstract:

SRY-related high-mobility group box 9 (SOX9), as one member of the SOX family, is confirmed to be significantly involved in tumorigenesis. Nowadays, cancer treatment has been improved from traditional treatments like operation, radiotherapy and chemotherapy to the molecule-targeted treatment which targets the aberrant genes that are related to tumorigenesis. Therefore, it’s urgent to find new therapeutic targets for patients who are resistant to chemotherapy. Previous studies have demonstrated that SOX9 is closely related to tumor initiation, proliferation and migration because it can regulate multiple signaling pathways, such as Wnt signaling, Notch signaling etc, and diverse target genes. In this review, we first demonstrate the molecular structure and the physiological functions of SOX9. Next, we analyze the SOX9 expression profile in various human tumors in the Oncomine database. Finally, we summarize the molecular mechanisms underlying SOX9 pathological functions in various tumors. Ultimately, understanding the role of SOX9 in tumorigenesis will provide new insights into utilizing SOX9 as a potential therapeutic target for patients who developed acquired chemoresistance.

Communication Author：QI Yi-Tao , Email:qiyitao@snnu.edu.cn MA Jiao , Email:drjiaoma@shsmu.edu.cn