《生命科学》 2020, 32(9): 985-991

热休克蛋白HSP72与非酒精性脂肪性肝病关系的研究进展

董云霞^1,2 , 陈　静^1,2 , 任　进^1,2,*

¹中国科学院上海药物研究所，上海 201203 ²中国科学院大学，北京 100049

摘　要：

非酒精性脂肪性肝病(nonalcoholic fatty liver disease, NAFLD) 是一种普遍流行且以慢性肝脏损伤为主要特征的代谢性疾病，具体表现为肝细胞内发生脂肪变性，伴随炎症和纤维化，最终可发展为肝硬化和肝癌。NAFLD 的诱发因素复杂，发病机制尚不明确，仍然缺乏有效的治疗措施。热休克蛋白72 (heat shock protein 72, HSP72)，是HSP70 家族中经典的诱导性应激蛋白，具有广泛的细胞保护作用。研究表明，HSP72 在NAFLD 病程中表达异常，且过表达HSP72 可以缓解肝损伤。现总结目前HSP72 在NAFLD 中的生物学功能及相关机制研究进展，并对此蛋白在NAFLD 研究领域的发展前景及未来研究方向进行展望。

通讯作者：任　进 , Email:jren@cdser.simm.ac.cn

The research progress of heat shock protein 72 and nonalcoholic fatty liver disease

DONG Yun-Xia^1,2 , CHEN Jing^1,2 , REN Jin^1,2,*

¹Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China ²University of Chinese Academy of Sciences, Beijing 100049, China

Abstract:

Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic disease characterized by chronic liver damage. It is mainly manifested by hepatic steatosis, accompanied by inflammation and fibrosis, which can eventually develop into cirrhosis and hepatocellular carcinoma. The pathogenesis of NAFLD is complex and not yet completely clear. Currently, there is no effective treatment for NAFLD. Heat shock protein 72 (HSP72), a classic, stress-inducible protein in the heat shock protein 70 family, displays versatile cytoprotective effect during stressful conditions. Some studies have demonstrated that HSP72 is abnormally expressed in the course of NAFLD and overexpression of HSP72 can ameliorate liver damage. This article summarizes the current research progress of biological functions and related mechanisms of HSP72 in NAFLD, and also discusses its prospect and future research direction.

Communication Author：REN Jin , Email:jren@cdser.simm.ac.cn