《生命科学》 2020, 32(9): 945-952

TBK1在肿瘤中的作用机制及其抑制剂的研究进展

沙　敏¹ , 胡晓川² , 王　颖^1,*

¹中国药科大学生命科学与技术学院，南京 210009 ²山东省青岛市中心医院职业病科，青岛 266042

摘　要：

TANK结合激酶1 (TANK-binding kinase 1, TBK1)通过调节干扰素和NF-κB信号通路在先天免疫反应中扮演着重要的角色，而免疫异常与恶性肿瘤的发生密切相关。最近的研究发现，TBK1在多种肿瘤细胞中呈现高水平表达和活性增强，这说明TBK1在多种肿瘤的发生发展中发挥了一定的作用，暗示了靶向TBK1在癌症治疗中的潜力。该文就TBK1的激活机制、其介导癌细胞生长的机制及TBK1抑制剂展开重点介绍。

通讯作者：王　颖 , Email:s15651676652@126.com

Advances in the mechanism of TBK1 in tumor and its inhibitors

SHA Min¹ , HU Xiao-Chuan² , WANG Ying^1,*

¹School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China ²Department of Occupational Disease, Qingdao Central Hospital, Qingdao 266042, China

Abstract:

TBK1 plays an important role in innate immune system by regulating interferon and NF-κB signaling pathway, and immune deficiency is closely related to cancers. Recent studies have shown that the expression and activity of TBK1 were increased in a variety of tumors, suggesting that TBK1 is involved in the development and progression of multiple tumors and targeting TBK1 has potential therapeutic benefit. Collectively, this review summarizes the potentially prooncogenic role of TBK1, as well as the correlative signals and inhibitors, which might shed light on the developing therapeutic strategies against tumors.

Communication Author：WANG Ying , Email:s15651676652@126.com