《生命科学》 2020, 32(8): 845-854

GPCR在类风湿关节炎中的作用机制研究进展

于凤至^1,2 , 孙　朋^1,2,*

¹华东师范大学体育与健康学院，上海 200241 ²华东师范大学 “青少年健康评价与运动干预”教育部重点实验室，上海 200241

摘　要：

类风湿关节炎(rheumatoid arthritis, RA) 是一种以滑膜炎为特征的自身免疫性疾病，伴有异常免疫反应。G 蛋白偶联受体(G protein coupled receptor, GPCR) 是人体最大的跨膜受体家族，介导RA 的发生发展过程，其相关信号通路在RA 炎症和免疫应答过程中发挥重要作用。研究发现，GPCR/AC/cAMP 相关通路，如β2-ARs/AC/cAMP、EP2/4/AC/cAMP 和CXCR/AC/cAMP 等信号通路，以及相关调节蛋白，如GRK 和β-arrestins 等，可能参与RA 的淋巴细胞功能异常、血管生成及关节破坏等病理过程。由此，β2-ARs 等受体以及GRK 等调节蛋白可能作为RA 的潜在治疗靶标。现通过简要阐述GPCR 相关通路及其调节蛋白的特点，以期加深对GPCR 参与RA 调控的认识，为类风湿关节炎药物的开发提供新的思路。

通讯作者：孙　朋 , Email:psun@tyxx.ecnu.edu.cn

Research progress on the mechanism of GPCR in rheumatoid arthritis

YU Feng-Zhi^1,2 , SUN Peng^1,2,*

¹College of Physical Education and Health, East China Normal University, Shanghai 200241, China ²Key Laboratory of Adolescent Health Assessment and Exercise Intervention, Ministry of Education, East China Normal University, Shanghai 200241, China

Abstract:

Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis with abnormal immune response. As the largest transmembrane receptor family, G protein coupled receptor (GPCR) mediates the occurrence and development of RA, and its related signaling pathway plays a key role in RA inflammation and immune response. Previous studies have shown that GPCR/AC/cAMP pathways, including β2-ARs/AC/cAMP, EP2/4/AC/cAMP and CXCR/AC/cAMP, as well as regulatory proteins, including GRK and β-arrestins, can participate in pathological processes such as lymphocyte dysfunction, angiogenesis and joint destruction in RA. Therefore, the GPCR and regulatory proteins may serve as potential therapeutic targets for RA. This review
systematically described the characteristics of GPCR related pathways and their regulatory proteins, in order to deepen the understanding of GPCR involved in RA regulation and provide new ideas for the development of rheumatoid arthritis drugs.

Communication Author：SUN Peng , Email:psun@tyxx.ecnu.edu.cn