《生命科学》 2020, 32(8): 834-844

脐带间充质干细胞在糖尿病治疗中的研究进展

谢田琴 , 刘建萍^*

南昌大学第二附属医院，南昌 330006

摘　要：

糖尿病是一种以高血糖为特征的代谢性疾病，胰岛β 细胞功能衰竭和胰岛素抵抗是糖尿病的主要病因。然而，目前的治疗方法，如口服抗糖尿病药物及胰岛素注射，尚不能逆转胰岛β 细胞功能衰竭，而胰腺移植又受到供体来源的限制。随着干细胞与再生医学的发展，脐带间充质干细胞(umbilical cord mesenchymal stem cells, UC-MSCs) 由于来源丰富、免疫原性低、无伦理问题等，成为治疗糖尿病的理想细胞类型。现就UC-MSCs 在糖尿病治疗中的研究进展进行综述，为UC-MSCs 移植治疗糖尿病的临床应用研究提供参考。

通讯作者：刘建萍 , Email:liujpnfm@163.com

Advances in the study of umbilical cord mesenchymal stem cells in the treatment of diabetes mellitus

XIE Tian-Qin , LIU Jian-Ping^*

The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China

Abstract:

Diabetes is a metabolic disease characterized by hyperglycemia. Islet cell failure and insulin resistance are the main causes of diabetes. However, current treatments such as oral antidiabetic drugs and insulin injections cannot reverse islet cell failure, and pancreas transplantation is limited by donor sources. With the development of stem cell and regenerative medicine, umbilical cord mesenchymal stem cells (UC-MSCs), due to rich resources, low immunogenicity, and no ethical issues, become ideal cell types for the treatment of diabetes. This paper reviews the research progress of UC-MSCs in the treatment of diabetes, and provides references for the clinical application of UC-MSCs transplantation in the treatment of diabetes.

Communication Author：LIU Jian-Ping , Email:liujpnfm@163.com