《生命科学》 2020, 32(8): 831-836

小胶质细胞发育和功能的性别差异

刘　秀^1,2 , 刘　洋² , 李晓易¹ , 俞华莉^2,* , 朱筱娟² , 范亚军^1,*

¹长春师范大学生命科学学院，长春 130032 ²东北师范大学生命科学学院，长春 130024

摘　要：

小胶质细胞是神经系统的免疫细胞，参与调节神经系统的发育以及维持神经系统稳态。小胶质细胞的发育和功能存在显著的性别差异，可能是脑性分化的关键介质。该文总结了小胶质细胞在发育、免疫应答以及神经系统疾病中的性别特征，为研究脑性分化和神经系统疾病的性别差异提供理论参考。

通讯作者：俞华莉 , Email:yuhl178@nenu.edu.cn 范亚军 , Email:xiaofan0524@126.com

Sex differences in the development and function of microglia

LIU Xiu^1,2 , LIU Yang² , LI Xiao-Yi¹ , YU Hua-Li^2,* , ZHU Xiao-Juan² , FAN Ya-Jun^1,*

¹College of Life Science, Changchun Normal University, Changchun 130032, China ²College of Life Science, Northeast Normal University, Changchun 130024, China

Abstract:

Microglia are the immune cells of the nervous system and involved in the development of brain as well as in the maintaining of brain homeostasis. There are significant gender differences in the development and function of microglia, which may be the key medium for brain sexual differentiation. This review summarized gender characteristics of microglia in development, immune response and nervous system diseases, thus providing reference for the study of brain sexual differentiation as well as gender differences in nervous system diseases.

Communication Author：YU Hua-Li , Email:yuhl178@nenu.edu.cn FAN Ya-Jun , Email:xiaofan0524@126.com