《生命科学》 2020, 32(8): 816-822

甲基苯丙胺对中枢神经系统炎症的影响及机制研究进展

吴亚梅¹ , 王　上² , 朱婷娜¹ , 刘鹏亮² , 李恒松¹ , 赵永娜^1,4,* , 陆　地³ , 李利华² , 洪仕君^2,*

¹昆明医科大学药学院暨云南省天然药物药理重点实验室，昆明 650500 ²昆明医科大学法医学院，昆明 650500 ³昆明医科大学生物医学工程中心，昆明 650500 ⁴昆明医科大学国际教育学院，昆明 650500

摘　要：

甲基苯丙胺(methamphetamine, MA) 滥用可严重损害中枢神经系统，但其机制尚未完全阐明，且缺乏有效治疗药物。MA 滥用致中枢神经系统受损与小胶质细胞、星形胶质细胞、NF-κB、TNF-α、IL-6 和IL-1β 及其他一些与中枢神经系统炎症相关因子具有重要联系。现以甲基苯丙胺滥用和关键中枢神经系统炎症反应相关细胞、因子为关注点，重点阐述它们之间的关系，对该领域的研究进展进行综述。

通讯作者：赵永娜 , Email:mszhaoyn@163.com 洪仕君 , Email:kmhongshijun@ 126.com

Research progress on the effects of methamphetamine on central nervous system inflammation and the mechanism

WU Ya-Mei¹ , WANG Shang² , ZHU Ting-Na¹ , LIU Peng-Liang² , LI Heng-Song¹ , ZHAO Yong-Na^1,4,* , LU Di³ , LI Li-Hua² , HONG Shi-Jun^2,*

¹School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China ²School of Forensic Medicine, Kunming Medical University, Kunming 650500, China ³Biomedical Engineering Research Center, Kunming Medical University, Kunming 650500, China ⁴International Education School, Kunming Medical University, Kunming 650500, China

Abstract:

Methamphetamine (MA) abuse can severely damage the central nervous system, but its mechanism has not been fully elucidated and there is no effective treatment. The damage is inextricably linked to the changes of microglia, astrocytes, NF-κB, TNF-α, IL-6 and IL-1β and other factors related to the development of central nervous system inflammation. This review focuses on methamphetamine abuse and the key cells, factors of central nervous system inflammation to explain the relationship between them.

Communication Author：ZHAO Yong-Na , Email:mszhaoyn@163.com HONG Shi-Jun , Email:kmhongshijun@ 126.com