《生命科学》 2020, 32(8): 807-815

肠道微生态与自闭症研究进展

叶　晨 , 陈启仪 , 李　宁^* , 秦环龙

同济大学附属第十人民医院结直肠病专科，上海 200072

摘　要：

自闭症是一种弥漫性中枢神经系统发育障碍性疾病，目前缺少特效的治疗手段，给社会和家庭带来沉重的负担。许多自闭症患儿合并有消化系统症状，且与肠道微生态紊乱密切相关。给予肠道微生态干预后，自闭症患儿消化系统症状得到改善，同时沟通和社交能力也能得到提高，因此脑- 肠- 菌轴在自闭症的发生发展过程中可能起到重要作用。目前有许多动物和临床研究证实益生元、益生菌及粪菌移植等生物干预方法对自闭症治疗的安全性和有效性，但仍缺乏更高级别临床证据进一步证实其疗效。

通讯作者：李　宁 , Email:liningrigs@sina.vip.com

Advances in intestinal microecology and autism

YE Chen , CHEN Qi-Yi , LI Ning^* , QIN Huan-Long

Tenth People's Hospital of Tongji University, Shanghai 200072, China

Abstract:

The autism is a kind of diffuse disorder of the central nervous system. Specific biochemical diagnostic indicators and therapeutic means are lacking, bringing families and the society heavy burden. Many children with autism have digestive symptoms, which are closely related to intestinal microecology disorder. After the intervention of intestinal microecology, the digestive symptoms, communication and social skills of some children with autism were improved. Therefore, the brain-gut-microbiota axis may play an important role in the development of autism. Nowadays, more and more animal and clinical studies have confirmed the safety and effectiveness of biological intervention methods such as prebiotics, probiotics and fecal microbiota transplantation in the treatment of autism, but there is still a lack of high-level clinical evidence to further confirm their effectiveness.

Communication Author：LI Ning , Email:liningrigs@sina.vip.com