《生命科学》 2020, 32(8): 798-806

自噬在孤独症谱系障碍中的研究进展

张思铭 , 陈雨珊^*

武汉科技大学医学院，脑科学先进技术研究院，武汉 430065

摘　要：

孤独症谱系障碍(autism spectrum disorder, ASD) 是一种广泛性发育障碍，以社会交流障碍和刻板重复行为为主要临床表现。ASD 的发生受到遗传和环境等因素的影响，但具体发病机制尚未明确，且目前尚无有效治疗方法。自噬(autophagy) 是一种维持蛋白质和细胞稳态的庞大代谢系统，参与多种神经发育性疾病的遗传和分子发病机理，也参与调控ASD 样行为和疾病发生。该文着重探讨自噬在ASD 中的研究进展，分析自噬基因和通路蛋白等在ASD 中的调控作用，为ASD 的治疗干预提供潜在的靶标。

通讯作者：陈雨珊 , Email:yschen0101@126.com

Study on the role of autophagy in autism spectrum disorder

ZHANG Si-Ming , CHEN Yu-Shan^*

Medical College, Brain Science and Advanced Technology Institute, Wuhan University of Science and Technology, Wuhan 430065, China

Abstract:

Autism spectrum disorder (ASD) is a widespread developmental disorder characterized by deficits in social interactions, repetitive and stereotypic behaviors. Although ASD arise as a consequence of mutations in genes and environmental factors, the specific pathogenesis is still unclear and effective treatment is lacking. Autophagy is a large metabolic system involved in maintaining protein and cell homeostasis, which is also involved in the genetic and molecular pathogenesis of neurodevelopmental diseases and ASD-like behaviors. In this article, the role of
autophagy including autophagy associated gene (ATG) and related signaling pathways in ASD will be focused on, which provides potential targets for therapeutic intervention of ASD.

Communication Author：CHEN Yu-Shan , Email:yschen0101@126.com