《生命科学》 2020, 32(7): 754-761

间歇性断食的健康促进作用研究进展

高雪彬 , 林晓转 , 郭红辉^*

广东医科大学公共卫生学院，东莞 523808

摘　要：

近三十年来，我国肥胖及相关慢性病的发病率不断升高，呈现流行态势。间歇性断食(intermittent
fasting, IF) 可以强制性地减少热量摄入，使机体处于能量负平衡状态，实现减重的目的。现有研究表明，IF 还可以通过转变能量代谢模式、诱导自噬、调整生物学节律和肠道菌群组成等途径降低血糖、改善胰岛素抵抗和减轻炎症反应，从而促进机体健康。IF 对于代谢综合征、非酒精性脂肪性肝病和2 型糖尿病等肥胖相关慢性病的防治具有广阔应用前景，但其对长期体重管理的安全性和有效性仍有待系统研究。该文对IF的实施方式、健康促进作用及其作用机制研究进展进行综述，旨在为IF 的后续研究和临床应用提供参考
依据。

通讯作者：郭红辉 , Email:guohh1999@gdmu.edu.cn

A review of the health benefits of intermittent fasting

GAO Xue-Bin , LIN Xiao-Zhuan , GUO Hong-Hui^*

School of Public Health, Guangdong Medical University, Dongguan 523808, China

Abstract:

Over the past three decades, the incidence of obesity and its related chronic diseases in China has been increasing rapidly, and the problem is now approaching epidemic proportions. Intermittent fasting (IF) can compulsorily reduce the calorie intake, attain a negative energy balance, and help to reduce body weight. Previous studies demonstrated that IF can also decrease blood glucose levels, improve insulin resistance and inhibit inflammatory response through switching the mode of energy metabolism, stimulating autophagy, adjusting the
circadian rhythms and reshaping gut microbiota. IF has a broad application prospect in the prevention and treatment of obesity-related chronic diseases such as metabolic syndrome, non-alcoholic fatty liver disease and type 2 diabetes mellitus, but its safety and efficacy in long-term body weight management remains to be studied systematically.

Communication Author：GUO Hong-Hui , Email:guohh1999@gdmu.edu.cn