《生命科学》 2020, 32(7): 723-730

退化蛋白/上皮钠通道超家族成员的激活与调控机制

唐泽华¹ , 杨晓娜¹ , 卢向阳¹ , 牛友芽^1,2,* , 田　云^1,*

¹湖南农业大学生物科学技术学院，长沙 410128 ²湖南医药学院医学院，怀化 418000

摘　要：

退化蛋白/ 上皮钠通道(DEG/ENaC) 超家族是20 世纪90 年代发现的一类非电压依赖性的、阿米诺利敏感的钠离子选择性离子通道，其激活方式复杂多样，参与如囊肿性纤维化、焦虑及癫痫等多种生理病理过程，已成为多种疾病的潜在药物靶标。现就DEG/ENaC 超家族成员的结构、特异激活方式以及交互激活与调控机制进行综述。

通讯作者：牛友芽 , Email:niuyouya@sina.com 田　云 , Email:tianyun79616@163.com

Research on the activation and regulation mechanisms of DEG/ENaC superfamily

TANG Ze-Hua¹ , YANG Xiao-Na¹ , LU Xiang-Yang¹ , NIU You-Ya^1,2,* , TIAN Yun^1,*

¹College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China ²School of Medicine, Hunan University of Medicine, Huaihua 418000, China

Abstract:

Degenerin/epithelial sodium channel (DEG/ENaC) superfamily of ion channels consists of diverse
members of non-voltage-gated, amiloride-sensitive, sodium-selective cation channels, and were found in the 1990s. DEG/ENaCs, with variable activation mechanisms, are involved in various physiological and pathological process, such as cystic fibrosis, anxiety and epilepsy, which makes them potential drug targets for various disease. Here, we summarize the knowledge of structure, the specific activation mechanisms, the interactive activation and regulation mechanisms of DEG/ENaCs.

Communication Author：NIU You-Ya , Email:niuyouya@sina.com TIAN Yun , Email:tianyun79616@163.com