《生命科学》 2020, 32(6): 614-620

单增李斯特菌感染致妊娠失败的研究进展

李文艳1，陈滢滢1，刘纯甫1，李晓宁1，李雪晨1，张伟伟1，管越强2*

(1 河北大学基础医学院，保定 071001；2 河北大学生命科学学院，保定 071001)

摘　要：

摘　要：单增李斯特菌(Listeria monocytogenes， LM) 是一种在自然界广泛存在的食源性人兽共患病原菌，妊娠动物和孕妇感染后会导致妊娠失败。研究显示，LM 感染后随着血液循环到达胎盘，在其毒力因子( 内化素A、李斯特菌溶血素O、肌动蛋白聚合蛋白、InlP 蛋白等) 的作用下，首先靶定绒毛膜外滋养层细胞，再穿过合体滋养层细胞或绒毛细胞滋养层细胞到绒毛基质，再通过胎儿毛细血管感染胎儿；在此过程中，LM 诱导的胎盘细胞凋亡、母胎界面细胞因子表达水平的改变和胎盘细胞炎性体的激活导致了妊娠失败。该文对上述问题就国内外最新研究进展进行综述和探讨。

Research progress on pregnancy failure induced by Listeria monocytogenes infection

LI Wen-Yan1， CHEN Ying-Ying1， LIU Chun-Fu1， LI Xiao-Ning1， LI Xue-Chen1， ZHANG Wei-Wei1， GUAN Yue-Qiang2*

(1 College of Basic Medicine， Hebei University， Baoding 071001， China; 2 College of Life Science， Hebei University， Baoding 071001， China)

Abstract:

Abstract: Listeria monocytogenes (LM)， an important foodborne zoonotic pathogen， is widely found in nature. When pregnant women and animals were infected， LM can induce pregnancy failure. Research reveals LM can arrive at the placenta with blood circulation in the organism. With the help of its virulence factors such as internalin A， Listeriolysin O， actin polymerzing protein and InlP protein， LM first targets extravillous trophoblast cells and subsequently disseminates syncytiotrophoblast cells or villious cytotrophoblast cells. Then it crosses the villous stroma to fetal capillaries and infects the fetus. Placental apoptosis， the changes of cytokines at maternal-fetal interface and the activation of placental cell inflammasomes play important roles in LM pregnancy failure. In this review， the above-mentioned issues were discussed based on the recent research progress.