《生命科学》 2020, 32(6): 606-613

硒蛋白S与2型糖尿病

喻保军，陈龙菊*

(湖北民族大学医学部解剖教研室，恩施 445000)

摘　要：

摘　要：硒是哺乳动物不可缺少的微量元素，在人体内通过硒蛋白形式发挥多种生物学功能。早期的研究证实硒具有胰岛素样作用，补硒或硒蛋白可预防和治疗2 型糖尿病(type 2 diabete mellitus， T2DM)。硒蛋白S (Selenoprotein S， SelS) 参与机体内质网相关降解通路、氧化应激、炎症反应，并对血糖、血脂具有调控作用；同时，SelS 异常表达于T2DM 患者体内，参与胰岛素抵抗，并诱发血管病变。该文综述硒蛋白S 基因的表达调控、生物学作用、代谢调节，以及与T2DM 相关的研究，为T2DM 的治疗提供理论依据。

Selenoprotein S and type 2 diabetes mellitus

YU Bao-Jun， CHEN Long-Ju*

(Department of Anatomy， Health Science Center， Hubei Minzu University， Enshi 445000， China)

Abstract:

Abstract: Selenium is an indispensable trace element for mammals. It plays a variety of biological roles in the human body through the form of selenoproteins. Earlier studies confirmed that selenium has an insulin-like effect， and selenium or selenoprotein supplementation can be used to prevent and treat type 2 diabetes mellitus (T2DM). Selenoprotein S (SelS) participates in the body's endoplasmic reticulum-related degradation pathways， oxidative stress， and inflammation response， and has a regulatory effect on blood glucose and blood lipids. Meanwhile， selenoprotein S is abnormally expressed in T2DM patients， which is involved in insulin resistance and induces vascular disease. This article reviews the expression regulation of selenoprotein S gene， biological effects， metabolic regulation， and relationship with T2DM， and provides a theoretical basis for the treatment of T2DM.