《生命科学》 2020, 32(6): 590-596

免疫细胞在脊髓损伤后炎性微环境中的作用

宋　强，张　红*，罗　兰，王　钦，梁　艳

(成都医学院第一附属医院急诊科，成都 610500)

摘　要：

摘　要：脊髓损伤(spinal cord injury， SCI) 的治疗和康复一直是临床医学领域的重大难题。现代医学虽然显著提高了脊髓损伤患者的存活率，然而在改善患者损伤神经功能方面进展甚微，其原因主要在于脊髓损伤后复杂的病理生理变化。在脊髓损伤的病理过程中，原发性损伤对脊髓神经结构的伤害难以逆转，因此目前国内外研究治疗脊髓损伤的方法主要围绕减轻继发性损伤和促进再生来开展。SCI 后炎症反应始终存在，这与免疫细胞在炎症反应的不同时间、不同损伤部位发挥不同作用密切相关。该文就免疫细胞在SCI 后炎症微环境中的作用做一简要综述。

The research progress of immune cells in inflammatory microenvironment after spinal cord injury

SONG Qiang， ZHANG Hong*， LUO Lan， WANG Qin， LIANG Yan

( Department of Emergency， the First Affiliated Hospital of Chengdu Medical College， Chengdu 610500， China )

Abstract:

Abstract: It has been a major problem of treatment and rehabilitation of spinal cord injury in the clinical medical field. The latest medical techniques significantly improved the survival rate of patients with SCI. However， there has been small progress on treatment options for improving the neurological function outcomes of SCI patients， because of the complex pathophysiology after spinal cord injury. Primary injuries of the spinal cord are irreversible in the pathological process of spinal cord injury. At present， most studies on treating spinal cord injury focused on reducing secondary injury and promoting regeneration. The inflammatory response has been existed after spinal cord injury， which is closely related to the different roles of immune cells at different time and in different injury sites. This article briefly reviews the role of immune cells in the inflammatory microenviroment after spinal cord injury.