《生命科学》 2020, 32(6): 551-557

哺乳动物生物钟与肠道菌群关系的研究进展

熊勇红，邹怡欣，时雨杰，张雯翔，陈思禹，刘　畅*

(中国药科大学生命科学与技术学院，南京 211198)

摘　要：

摘　要：为适应昼夜交替所带来的外界环境的变化，大多数生物的生理活动会表现出以24 h 为周期的节律性变化，这种现象称为生物节律( 又称生物钟)。生物钟紊乱会增加相关代谢性疾病的风险，这些疾病的发展与肠道菌群失调密切相关。肠道菌群即为人体胃肠道内寄生的一定数量和种类的微生物群落。正常情况下，肠道菌群处于平衡状态；但当宿主生物节律受到外界环境干扰时，其肠道菌群稳态也会发生失衡。越来越多的研究显示，肠道菌群的紊乱导致了代谢性疾病的发生。现对生物钟、肠道菌群以及代谢性疾病的关系进行论述，从而为治疗代谢性疾病提供新的策略。

Research progress of interaction between circadian clock and gut microbiota in mammals

XIONG Yong-Hong， ZOU Yi-Xin， SHI Yu-Jie， ZHANG Wen-Xiang， CHEN Si-Yu， LIU Chang*

(School of Life Science and Technology， China Pharmaceutical University， Nanjing 211198， China)

Abstract:

Abstract: To adapt the changes of the external environment induced by the day/night cycle， physiological activities of most creatures exhibit diurnal alterations within a 24-hour rhythm， this phenomenon is known as biological rhythm (circadian clock). Disruption of the circadian clock causes metabolic diseases， which is also closely associated with dysfunction of the gut microbiota. Gut microbiota is a cluster of bacterial species in the human gastrointestinal tract. At normal condition， the gut microbiota is in equilibrium. When the biological rhythm of host is disturbed by the external stimulus， the homeostasis of gut microbiota will be out of balance. Therefore， the dysbiosis of gut microbiota is tightly closed to the development of metabolic diseases. This review summarizes the relationships among circadian clock， gut microbiota and metabolic diseases， thus provides potential therapeutic strategies for metabolic diseases.