《生命科学》 2020, 32(5): 494-500

黄酮醇及其改良剂型抗乳腺癌研究进展

黄曦文1，2，何　刚1，2，伍春莲1，2*

(1 西南野生动植物资源保护教育部重点实验室，南充 637009；2 西华师范大学生命科学学院，南充 637009)

摘　要：

摘　要：乳腺癌是女性最常见的癌症。黄酮醇是一类具有抗癌活性且毒副作用小的多酚类天然化合物。该文从阻滞细胞周期、促进细胞凋亡、抑制侵袭转移、影响肿瘤细胞糖代谢、与其他药物联用、化疗增敏及逆转耐药等方面，就三种最常见的黄酮醇化合物( 芦丁、槲皮素、山奈酚) 及其衍生物和改良剂型抗乳腺癌的研究进展作一综述。

Research progress of flavonols and its modified dosage forms against breast cancer

HUANG Xi-Wen1，2， HE Gang1，2， WU Chun-Lian1，2*

(1 Key Laboratory of Southwest China Wildlife Resource Conservation， Ministry of Education， Nanchong 637009， China; 2 College of Life Science， China West Normal University， Nanchong 637009， China)

Abstract:

Abstract: Breast cancer is the most common cancer in women. Flavonols are a class of natural polyphenolic compounds with anticancer activity and low toxicity. In this paper， the three most common flavonol compounds (rutin， quercetin， kaempferol)， their derivatives and modified dosage forms for anti-breast cancer are reviewed from the aspects of cell cycle arrest， cell apoptosis promotion， invasion and metastasis inhibition， the effect on tumor cell glucose metabolism， combined with other drugs， chemosensitivity enhancement and drug resistance reversal.