《生命科学》 2020, 32(5): 471-476

细胞衰老在非酒精性脂肪性肝病发生发展中的作用

刘小慧，曾俊豪，万小雨，刘朝奇*

(三峡大学肿瘤微环境与免疫治疗湖北省重点实验室，宜昌 443002)

摘　要：

摘　要：细胞衰老是细胞在受到内外环境的损伤作用后被激活的一种细胞应答状态，可作为一种固有的细胞保护机制用于抵抗这些损伤刺激。然而，长时间持续的细胞衰老状态则与炎症、纤维化以及恶性肿瘤的发生有着密切的关系，其中在非酒精性脂肪性肝病的发生发展中细胞衰老扮演着重要的角色。因此，探讨细胞衰老在非酒精性脂肪性肝病发生发展中的作用，并发现其可能用于临床治疗的分子靶点及其作用机制具有重要意义。

Cellular senescence in the progression of NAFLD

LIU Xiao-Hui， ZENG Jun-Hao， WAN Xiao-Yu， LIU Chao-Qi*

(Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy， China Three Gorges University， Yichang 443002， China)

Abstract:

Abstract: Cellular senescence is a cellular response triggered by the damage of cell's internal and external environment， so it is viewed as inherent cellular protection mechanism to resist various stimuli. However， the sustained effects of cell senescence are closely related to inflammation， fibrosis and cancer. Particularly， cell senescence plays an important role in the development of nonalcoholic fatty liver disease (NAFLD). Therefore， it makes sense to ascertain the mechanisms of cellular senescence in the development of NAFLD and explore the probable therapeutic targets.