《生命科学》 2020, 32(5): 431-438

NF-κB家族成员RelA的翻译后修饰及其生理病理作用的研究进展

耿云峰1，2，杜鸿斌1，刘琳琳1，孙梦莹1，鞠吉雨3，张杰彪1，赵春玲1*，田春艳2*

(1 潍坊医学院山东省高校生物药物重点实验室，潍坊 261053；2 军事科学院军事医学研究院
    生命组学研究所，北京 100850；3 潍坊医学院山东省高校免疫学重点实验室，潍坊 261053)

摘　要：

摘　要：真核细胞转录因子NF-κB 通过调节多种靶基因表达，参与炎症、免疫反应、程序性细胞死亡、细胞增殖和分化的调控。RelA 是NF-κB 家族一个重要的成员，其翻译后修饰可精准调控NF-κB 的转录活性，在调节炎症、肿瘤、代谢以及免疫应答等重要的生命活动及相关疾病的发生发展过程中起重要作用。现总结相关领域最新研究进展，综述RelA 翻译后修饰的种类、调控机制，对NF-κB 通路功能的影响，及其在NF-κB 介导的炎症、癌症等多种疾病中的功能。

Research progress on post-translational modification of NF-κB family member RelA and its physiological and pathological effects

GENG Yun-Feng1，2， DU Hong-Bin1， LIU Lin-Lin1， SUN Meng-Ying1， JU Ji-Yu3， ZHANG Jie-Biao1， ZHAO Chun-Ling1*， TIAN Chun-Yan2*

(1 Key Laboratory of Biopharmaceutics in Universities of Shandong Province， Weifang Medical University， Weifang 261053， China; 2 Institute of Life Science， Military Medical Research Institute， Academy of Military Sciences， Beijing 100850， China; 3 Key Laboratory of Immunology in Universities of Shandong Province， Weifang Medical University， Weifang 261053， China)

Abstract:

Abstract: The eukaryotic transcription factor NF-κB is involved in the regulation of inflammation， immune response， programmed cell death， cell proliferation and differentiation by regulating the expression of multiple target genes. RelA is one of the most important members of the NF-κB family. Its post-translational modification can precisely regulate the transcriptional activation of NF-κB， and plays an important role in inflammation， tumor， metabolism， immune， and the occurrence and development of related diseases. In this review， we summarized the types， regulatory mechanisms， effects of post-translational modifications of RelA， and discussed its functions in various diseases such as NF-κB-mediated inflammation and cancer.