《生命科学》 2020, 32(4): 396-402

5羟色胺与钙化性主动脉瓣疾病研究进展

董照瀛，周晓莉*

(重庆医科大学附属第一医院心血管内科，重庆 400042)

摘　要：

摘　要：钙化性主动脉瓣疾病(calcified aortic valve disease， CAVD)是一组与年龄相关的瓣膜疾病，治疗方法有限，除对晚期瓣膜钙化患者进行瓣膜置换术外，尚无有效的药物干预措施。因此，深入了解瓣膜重塑和疾病进展早期的分子机制，是今后预防甚至逆转此类疾病的关键环节。5羟色胺(5-HT)作为一种调节中枢和外周功能的内源性单胺类激素，与类癌心脏病、药物性瓣膜病和老年小型犬类的瓣膜退化都有十分密切的联系，并且参与了瓣膜炎症、纤维化、钙化等病理进程中的每个环节。该文综述了5-HT系统与心脏瓣膜的关系，为今后深入研究该系统与钙化性主动脉瓣疾病的关系提供了可能。

Research progress on 5-hydroxytryptamine and calcified aortic valve disease

DONG Zhao-Ying， ZHOU Xiao-Li*

(Cardiovascular Department， The First Affiliated Hospital of Chongqing Medical University， Chongqing 400042， China)

Abstract:

Abstract: Calcific aortic valve disease is a group of age-related valvular diseases. Currently， there are no effective medical interventions. The treatment is limited to percutaneous or surgical valve replacement for patients with advanced valve calcification. Therefore， in-depth understanding of the early molecular mechanism of valve remodeling and disease progression is the key to prevent or even reverse such diseases in the future. Serotonin (5-HT)， as an endogenous monoamine hormone regulating central and peripheral functions， is closely associated with carcinoid heart disease， drug-induced valvular disease and valvular degeneration in elderly small dogs， and is involved in every step of the pathological process such as valvular inflammation， fibrosis and calcification. This paper reviewed the relationship between 5-HT system and heart valve， providing the possibility for further research on the relationship between 5-HT system and calcified aortic valve disease.