《生命科学》 2020, 32(4): 387-395

miR-146a的功能及其靶基因的研究进展

谭俊龙1，2，郑明霞1，2，刘湘宁1，2，3，王晓刚1，3*

(1 暨南大学附属第一医院，广州 510632；2 暨南大学口腔医学院，广州 510632；3 暨南大学口腔交叉学科临床研究平台，广州 510632)

摘　要：

摘　要：微小RNA (microRNA， miRNA)是小分子非编码RNA 中的一类，可与靶mRNA结合，降解或抑制该mRNA 进行翻译，进而对细胞的生长、增殖、衰老等过程进行调控。miRNA-146a(miR-146a)与炎性因子所致的自身免疫性疾病以及肿瘤的侵袭和转移相关，其失调往往导致病情的加重。然而，目前相关疾病常用的临床诊断指标和治疗药物缺乏特异性。现以miR-146a为切入点，为寻找相关的自身免疫性疾病以及肿瘤更加精准的早期诊断指标和治疗靶点提供线索。

Advances in the function and target genes of miR-146a

TAN Jun-Long1，2， ZHENG Ming-Xia1，2， LIU Xiang-Ning1，2，3， WANG Xiao-Gang1，3*

(1 The First Affiliated Hospital of Jinan University， Guangzhou 510632， China;
    2 College of Stomatology， Jinan University， Guangzhou 510632， China; 3 Clinical Research Platform for Interdiscipline of Stomatology， Jinan University， Guangzhou 510632， China)

Abstract:

Abstract: MicroRNAs (miRNAs) are a class of small noncoding RNAs that can regulate various cellular processes (e.g.， growth， proliferation， and aging) by binding to target mRNAs， thereby causing their degradation or inhibiting their translation. miRNA-146a (miR-146a) is associated with autoimmune diseases caused by inflammatory factors as well as with tumor cell invasion and metastasis. The dysregulation of miR-146a often leads to the aggravation of these diseases. However， the clinical diagnostic indicators and therapeutic drugs that are commonly used for these diseases lack specificity. In this review， miR-146a was used as an entry point to identify more accurate indicators for the early diagnosis of autoimmune diseases and tumors and their therapeutic targets.