RNA m6A甲基化修饰对生物学功能调控作用的研究进展

姚牧笛,马 严,蒋 沁*
(南京医科大学附属眼科医院,南京 210029)

摘 要:

摘 要:目前发现的RNA 表观遗传修饰存在多种方式,如N6-甲基腺嘌呤(N6-methyladenosine, m6A)、N1-甲基腺嘌呤(N1-methyladenosine, m1A)、5-甲基胞嘧啶(5-methylcytidine, m5C)和假尿嘧啶核苷(pseudouridine, PD)等。m6A是最常见的一种修饰,它是由甲基转移酶和去甲基化酶以及结合蛋白所催化的一种动态可逆的修饰方式,具有重要的调控功能,参与多种细胞进程和疾病的病理过程。最近5年,随着RNA检测技术的发展,m6A修饰的生物学功能探索已成为RNA 领域的前沿热点,该文拟对m6A甲基化修饰的相关蛋白、生物学功能等方面进行简要概述。

Advances in biological function regulation by RNA m6A methylation
YAO Mu-Di, MA Yan, JIANG Qin*
(The Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210002, China)


Abstract: There are multiple ways of RNA epigenetic modification including N6-methyladenosine (m6A), N1-methyladenine (m1A), 5-methylcytosine (m5C) and pseudouridine (PD) and so on. m6A is the most prevalent modified nucleotide in eukaryotic mRNA, which is a dynamic and reversible modification mode catalyzed by writers, erasers and readers. m6A has important regulatory functions and participates in a variety of cellular processes and pathological processes of diseases. In recent 5 years, with the development of RNA detection echnologies, the exploration of biological functions of m6A has become a research frontier hotspot. This review gived a brief description of regulatory proteins and biological functions of m6A.

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