摘 要：摘 要：作为基因组研究的延伸，蛋白质组学已成为世界生命科学领域的一个极其活跃的部分，是功能基因组时代或后基因组时代的核心。近年来发展起来的几种蛋白质组学新技术克服了传统蛋白质组学技术的不足，有力推进了肿瘤标志物的探索性研究。尽管如此，我们仍应该强调对实验结果的验证，这一点在探索性研究中尤其重要，力求使结果更精确、可靠和有效。
关键词：蛋白质组；肿瘤标志物；激光捕获显微切割；飞行时间质谱；质谱成像
Abstract: Abstract: With the development in genomic research, protemics has become an extremely active and increasingly important part of the worldwide life science research and the core of the functional genomics era or the "post-genomic era" Several new technologies in proteomics developed in the past few years greatly boosted the discovery-based research of tumor markers beyond the disadvantages of traditional approaches. Nevertheless, rules of evidence to access the validity of results, important in any research, are crucial in discovery-based research. Follow these rules, some current problems might be predictable and avoidable so that results could be of accuracy, precision and effectiveness.
Key words: proteomics; tumor marker; laser capture microdissection; TOF-MS; imaging MS
