《生命科学》 2020, 32(4): 359-365

TRIM25在抗病毒天然免疫及恶性肿瘤发生发展中作用的研究进展

李三中1，2，唐旭东1，2*

(1 广东医科大学生物化学与分子生物学研究所，湛江 524023；2 广东医科大学抗肿瘤活性物质研发协同创新中心，湛江 524023)

摘　要：

摘　要：三基序蛋白25 (tripartite motif 25， TRIM25)是一种E3泛素连接酶，其介导的维甲酸诱导基因Ⅰ(retinoic acid-inducible gene I， RIG-I)泛素化是启动细胞内抗病毒反应的重要步骤。近期研究发现，TRIM25还能通过其他途径调节宿主抗病毒能力，包括RIG-Ⅰ的负调节、黑色素瘤分化相关基因5(melanoma differentiation-associated gene 5， MDA5)的激活、增强锌指抗病毒蛋白(zinc-finger antiviral protein， ZAP) 活性、抑制病毒RNA合成。与此同时，病毒与宿主能通过多种机制调节TRIM25，包括泛素化降解、与细胞和病毒RNA 结合、与RIG-Ⅰ的结合、竞争TRIM25作用底物。TRIM25在肺癌、前列腺癌、肝癌、乳腺癌、胃癌、结直肠癌等恶性肿瘤的发生发展中也发挥重要作用。为了更好地了解TRIM25 在抗病毒天然免疫与肿瘤发生发展中的作用及其机制，现对近年TRIM25在这两方面的研究进展进行总结。

Research progress of TRIM25 in antiviral innate immunity and occurrence and development of malignant tumors

LI San-Zhong1，2， TANG Xu-Dong1，2*

(1 Institute of Biochemistry and Molecular Biology， Guangdong Medical University， Zhanjiang 524023， China; 2 Collaborative Innovation Center for Antitumor Active Substance Research and Development， Guangdong Medical University， Zhanjiang 524023， China)

Abstract:

Abstract: Tripartite motif 25 (TRIM25)， an E3 ubiquitin ligase， the retinoic acid-inducible geneⅠ(RIG-Ⅰ) ubiquitination mediated by TRIM25 is an important step in the initiation of antiviral response in the cells. Recent studies have found that TRIM25 can regulate the antiviral ability of hosts through other ways， including negative regulation of RIG-Ⅰ， activation of melanoma differentiation associated gene 5 (MDA5)， enhancement of zinc-finger antiviral protein (ZAP) activity and inhibition of viral RNA synthesis. At the same time， viruses and hosts can regulate TRIM25 through a variety of mechanisms， including ubiquitination degradation， binding to cellular and viral RNA， binding to RIG-Ⅰ and competing for TRIM25 substrates. TRIM25 also plays an important role in malignant tumors including lung cancer， prostate cancer， liver cancer， breast cancer， gastric cancer and colorectal cancer. In order to better understand the roles and mechanisms of TRIM25 in the antiviral innate immunity and the occurrence and development of tumorigenesis， this paper summarizes the research progress of TRIM25 in these two aspects.