《生命科学》 2020, 32(4): 325-334

造血微环境细胞组成及功能的研究进展

迟亚男1，范书玥1，2，3，马　姬1，薛　燕1，2，3，曾凡一1，2，3*

(1 上海交通大学医学院组织胚胎学与遗传发育学系，上海 200025；2 上海市儿童医院上海医学遗传研究所，上海 200040；3 上海市胚胎与生殖工程重点实验室，国家卫生和计划生育委员会医学胚胎分子生物学重点实验室，上海 200040)

摘　要：

摘　要：造血微环境是造血干细胞(HSCs)居住的场所，对于维持HSCs 自我更新、分化与稳态有着重要的调控作用。伴随着胚胎发育，造血主要分为卵黄囊造血、主动脉-性腺-中肾造血、胎肝造血及骨髓造血4个时期，因而研究造血发育时期的微环境对体外HSCs的扩增及诱导分化有着重要的指导意义。现对4个造血时期的造血微环境细胞组成及功能进行综述，阐明不同时期造血微环境调控作用的异同，为实现HSCs在体外的扩增与分化打下基础。

Advances in research on cell composition and function of hematopoietic microenvironment

CHI Ya-Nan1， FAN Shu-Yue1，2，3， MA Ji1， XUE Yan1，2，3， ZENG Fan-Yi1，2，3*

(1 Department of Histoembryology， Genetics & Development， Shanghai Jiao Tong University School of Medicine， Shanghai 200025， China; 2 Shanghai Institute of Medical Genetics， Shanghai Children’s Hospital， Shanghai 200040， China; 3 Key Laboratory of Embryo Molecular Biology， Ministry of Health & Shanghai Key Laboratory of Embryo and Reproduction Engineering， Shanghai 200040， China)

Abstract:

Abstract: The hematopoietic microenvironment hosts the hematopoietic stem cells (HSCs). It also plays an essential role in regulating the self-renewal， differentiation， and homeostasis of HSCs. During embryonic development， hematopoiesis can be divided into four stages: yolk sac hematopoiesis， aortic-gonadal-medullary hematopoiesis， fetal liver hematopoiesis， and bone marrow hematopoiesis. Therefore， hematopoietic microenvironment has a profound impact on the expansion and differentiation of HSCs in vitro or in vivo. In this paper， the composition and function of hematopoietic microenvironment cells during the four stages were reviewed， and the differences in regulating hematopoiesis were described， which may help lay a solid foundation for the expansion and differentiation of HSCs in vitro.