《生命科学》 2020, 32(3): 245-256

梯度信号分子功能支架的制备及再生医学应用

张海敏1，2，陈珍妮2，3，庄　燕2，沈　贺2，陈艳艳2，李晓然4*，戴建武2，5*

(1 西安交通大学药学院， 西安 710061；2 中国科学院苏州纳米技术与纳米仿生研究所，中国科学院纳米生物界面研究重点实验室，苏州 215123；3 中国科学技术大学纳米科学技术学院，苏州 215123；4 东华大学纺织科技创新中心，上海 200051；5 中国科学院遗传与发育生物学研究所，分子发育生物学国家重点实验室，北京 100080)

摘　要：

摘　要：再生医学作为新兴的治疗手段，为受损组织再生带来新希望。如何实现生物支架的功能化是提高受损组织再生能力的关键因素之一。天然生物体内存在多种物理、化学信号梯度，调控多种生理学过程，促进细胞黏附、迁移和分化，从而提高组织损伤修复效果。近年来，研究发现在生物支架中引入梯度分布的物理或生物学信号，在组织修复及再生方面展现出独特作用，具有重大应用前景。该文阐述了近年来组织再生中信号梯度功能支架的分类、制备技术及其在再生医学中的研究进展，并对再生医学领域梯度功能支架进行展望。

The recent progress in fabrication and regenerative medicine applications of    signaling gradient biomaterial scaffolds

ZHANG Hai-Min1，2， CHEN Zhen-Ni2，3， ZHUANG Yan2， SHEN He2， CHEN Yan-Yan2， LI Xiao-Ran4*， DAI Jian-Wu2，5*

(1 School of Pharmacy， Xi’an Jiaotong University， Xi’an 710061， China; 2 CAS Key Laboratory for Nano-Bio Interface Research， Division of Nanobiomedicine， Suzhou Institute of Nano-Tech and Nano-Bionics， Chinese Academy of Sciences，
    Suzhou 215123， China; 3 Nano Science and Technology Institute， University of Science and Technology of China， Suzhou 215123， China; 4 Innovation Center for Textile Science and Technology， Donghua University， Shanghai 200051， China;
    5 State Key Laboratory of Molecular Developmental Biology， Institute of Genetics and Developmental Biology， Chinese Academy of Sciences， Beijing 100080， China)

Abstract:

Abstract: Regenerative medicine， as an emerging treatment， has brought new hope to the regeneration of damaged tissues. One of the key factors is  functionalization of the biomaterial scaffolds to improve the capability of tissue repair. In the natural human body， there are a variety of physical and chemical gradients in vivo， which facilitate cell adhesion， migration and differentiation， and promote the tissue regeneration eventually. In recent years， a large number of gradient biomaterial scaffolds have been developed， and showed a unique capability and great potential in tissue regeneration. The objective of the review is to systematically describe the recent progress in fabrication and regenerative medicine applications of gradient biomaterial scaffolds. And we also discussed their future perspectives in regenerative medicine.