《生命科学》 2020, 32(2): 195-202

MicroRNA在糖尿病足溃疡中的调控机制和治疗前景

王虹舒1，3，黎晶晶2*，陆晟迪3，马中良4，柴益民1，3*
    

(1 上海交通大学医学院，上海 200025；2 浙江医药高等专科学校，宁波 315100；3 上海交通大学附属第六人民医院骨科， 上海 200233；4 上海大学生命科学学院非编码RNA与癌症实验室，上海 200444)

摘　要：摘　要：糖尿病足溃疡(diabetic foot ulcer， DFU) 是糖尿病主要并发症之一。微小RNA (microRNA， miRNA)是一种在转录后水平调控基因表达的、内源性、非编码单链小RNA。近年来的研究表明，miRNA 与DFU的炎症调控、血管新生、再上皮化等过程密切相关。MiRNA 靶向治疗的体外和体内实验研究展现出了miRNA 未来潜在的治疗价值。现就miRNA 在DFU 创面愈合的各阶段中的调控作用及其治疗应用的可能性两方面进行综述，为后续研究开拓新的思路。

Roles of miRNA in wound healing and therapeutic prospect of diabetic foot ulcer    

WANG Hong-Shu1，3， LI Jing-Jing2*， LU Sheng-Di3， MA Zhong-Liang4， CHAI Yi-Min1，3*
    

(1 Shanghai Jiao Tong University School of Medicine， Shanghai 200025， China;
    2 Zhejiang Pharmaceutical College， Ningbo 315100， China; 3 Department of Orthopaedics， Shanghai Jiao Tong University Affiliated Sixth People’s Hospital， Shanghai 200233， China; 4 Lab for Noncoding RNA & Cancer， School of Life Sciences， Shanghai University， Shanghai 200444， China)

Abstract: Abstract: MicroRNA (miRNA) is a group of endogenous non-coding single-stranded small RNA which regulates gene expression at the post-transcriptional level. Recent studies have suggested that miRNA plays an important role in inflammation， angiogenesis， and re-epithelialization in the impaired wound healing process of diabetic foot ulcer (DFU). MiRNA-targeted therapeutics showed promising potentialities of treatment in the future based on plenty of researches. The objective of this review is to summarize the regulatory effects on wound healing of miRNA and its therapeutic potentialities in the treatment of DFU， shedding a light on the future.