《生命科学》 2020, 32(2): 170-178

高蛋白膳食干预对肥胖及相关慢性疾病的影响

温昀斐1，2#，岳凌生3#，慈宏亮1，2，慈晓丽1，4，王　欢1，2*

(1 特勒姆瑟营养科技(广东)有限公司，东莞 523808；2 科特勒医学技术发展(东莞)有限公司，松山湖国际精准医学园，Alpha Innovation，东莞 523808；3 中国科学院科技战略咨询
    研究院，北京 100190；4 肽康达生物科技(东莞)有限公司，东莞 523808)

摘　要：摘　要：目前我国超重和肥胖问题日益严重，并呈现流行态势。高蛋白膳食作为一种宏量营养素调节方式，可通过提高饱腹感、减少能量摄入、增加机体能量消耗形成能量负平衡，进而达到减重和改善代谢机能的作用。现有研究表明，高蛋白膳食对于短期体重管理具有积极作用，对于2 型糖尿病、脂肪肝和代谢综合征等肥胖相关疾病的营养治疗亦具有广阔应用前景，但其对长期体重管理的安全性和有效性，以及对肾脏和心血管疾病的潜在风险仍有待系统研究。

Effect of high protein diet intervention on obesity and related chronic diseases        

WEN Yun-Fei1，2#， YUE Ling-Sheng3#， CI Hong-Liang1，2， CI Xiao-Li1，4， WANG Huan1，2*

(1 Tromso Nutrition Technologies (Guangdong) Co.， LTD， Dongguan 523808， China; 2 Kotler Medical Technology Development (Dongguan) Co.，LTD， Kotler Medical Park， Alpha Innovation， Dongguan 523808， China; 3 Institutes of Science and Development， Chinese Academy of Sciences， Beijing 100190， China; 4 Taikangda Biotechnology (Dongguan) Co.， LTD， Dongguan 523808， China)

Abstract: Abstract: At present， overweight and obesity have been serious public health issues in China， and they are in a prevailing trend. As a macronutrient-regulated diet method， high-protein diet can form a negative balance of energy by increasing satiety， reducing energy intake， and increasing energy consumption of the body， thereby achieving weight loss and improving metabolic function. Current research shows high protein diet has a positive effect on short-term weight management， and it has broad application prospects for nutritional treatment of obesity-related diseases such as type 2 diabetes， fatty liver and metabolic syndrome. However， the safety and efficacy of high-protein diets for long-term weight management， as well as the impact on kidney function and the potential risks of cardiovascular diseases remain to be systematically studied.