《生命科学》 2020, 32(2): 162-169

DNA甲基化与骨代谢调节及骨质疏松症研究进展

牛亚丹，林伊荷，张汉清，陶　涛，徐雷艇*

(宁波大学医学院，宁波 315211)

摘　要：摘　要：骨质疏松症的根本病因是由于多种因素导致成骨细胞介导的骨形成与破骨细胞介导的骨吸收过程之间的负平衡，引起骨质进行性丢失，骨密度降低，骨脆性增加，进而导致骨折风险增加。越来越多的研究表明，DNA 甲基化可通过调控相关基因表达调节成骨细胞／破骨细胞的分化与功能，进而影响骨形成/骨吸收平衡，介导骨质疏松症的发生、发展。现主要阐述DNA 甲基化与骨代谢调节和骨质疏松症之间的关系，并对相关研究进展进行综述。

Research progress on the role of DNA methylation in bone metabolism regulation and osteoporosis    

NIU Ya-Dan， LIN Yi-He， ZHANG Han-Qing， TAO Tao， XU Lei-Ting*
    

(School of Medicine， Ningbo University， Ningbo 315211， China)

Abstract: Abstract: The ultimate etiology of osteoporosis is the negative balance between osteoblasts-mediated bone formation and osteoclasts-mediated bone resorption caused by multi-factors， which results in progressive loss of bone， decreased bone mineral density， increased bone fragility and hence increased risk of fracture. More and more studies have shown that DNA methylation plays an important role in the differentiation and function of osteoblasts/osteoclasts by regulating the expression of related genes， thereby affecting the balance of bone formation/resorption and mediating the occurrence and development of osteoporosis. This paper reviewed the recent research progress on the relationship between DNA methylation and bone metabolism regulation and osteoporosis.