《生命科学》 2020, 32(2): 149-154

DHA在肺癌防治中的研究进展

陈　晨1，任　静1，戴秋芹1，罗海清2，李祥勇1*

(1 广东医科大学生物化学与分子生物学研究所，抗肿瘤活性物质研发协同创新中心，广东省医学活性分子重点实验室，湛江 524023；2 广东医科大学附属医院，湛江 524000)
    

摘　要：摘　要：二十二碳六烯酸(docosahexaenoic acid， DHA) 是人体必需多不饱和脂肪酸omega-3 (n-3 polyunsaturated fatty acid， n-3 PUFA) 中的重要成员。流行病学调查显示深海鱼油中丰富的DHA 具有广泛的抗炎和 抗肿瘤作用，特别是在肺癌中，DHA 还作为潜在的抗癌营养素参与患者的营养干预治疗。为了全面了解DHA 在肺癌中的抗肿瘤作用，该文拟从DHA 在肺癌预防及治疗中的人群研究、DHA 在肺癌中的抗肿瘤作用机制和DHA 的联合治疗等三方面进行综述。

Research progress of DHA in the prevention and treatment of lung cancer

CHEN Chen1， REN Jing1， DAI Qiu-Qin1， LUO Hai-Qing2， LI Xiang-Yong1*

(1 Institute of Biochemistry and Molecular Biology， Collaborative Innovation Center for Antitumor Active Substance Research and Development， Key Laboratory of Medical Bioactive Molecular Research for Department of Education of Guangdong Province， Guangdong Medical University， Zhanjiang 524023， China; 2 Affiliated Hospital of Guangdong Medical University， Zhanjiang 524000， China)

Abstract: Abstract: Docosahexaenoic acid (DHA) is an important member of the essential omega-3 polyunsaturated fatty acids (n-3 PUFA). Epidemiological studies have shown that DHA， which is abundant in deep-sea fish oil， has a wide range of anti-inflammatory and anti-tumor effects. Especially in lung cancer， DHA is also involved in nutritional interventions for patients as a potential anti-cancer nutrient. In order to fully understand the anti-tumor effect of DHA in lung cancer， we review the population-based studies of DHA in prevention and treatment of lung cancer， the anti-tumor mechanism of DHA in lung cancer and the DHA-based combination therapy.