《生命科学》 2020, 32(2): 143-148

RASSF1A基因及其在结直肠癌中的研究进展

胡　斐1，陈　丽1，毕明瑜1，唐文如1，盛苗苗1，2*

(1 昆明理工大学医学院衰老与肿瘤分子遗传学实验室，昆明 650500； 2 云南省第一人民医院消化疾病内科研究所，昆明 650032)

摘　要：摘　要：结直肠癌发展的分子机制之一是抑癌基因CpG 岛甲基化。RASSF1A 位于3p21.3，参与了包括细胞周期调控、凋亡、微管稳定在内的多种生物进程，被认为是抑癌基因，在包括结直肠癌在内的多种肿瘤中因甲基化失活。近来研究发现，RASSF1A 的甲基化可能作为结直肠癌分子诊断的标志。本文就RASSF1A功能及其与结直肠癌的关系进行综述。

Role of the Ras-association domain family 1 isoform A in colorectal cancer        

HU Fei1， CHEN Li1， BI Ming-Yu1， TANG Wen-Ru1， SHENG Miao-Miao1，2*

(1 Laboratory of Molecular Genetics of Aging & Tumor， Medical School， Kunming University of Science and Technology， Kunming 650500， China; 2 Yunnan Provincial Institute of Digestive Medicine， The First People's Hospital of Yunnan Province， Kunming 650500， China)

Abstract: Abstract: One of the molecular mechanisms of colorectal cancer is the methylation of the tumor suppressor gene CpG island. Ras-association domain family 1 isoform A (RASSF1A) is a tumor suppressor gene located within a segment on chromosome 3p21.3， involving in cell cycle regulation， apoptosis and microtubule stability， and is inactivated by hypermethylation in various tumors including colorectal cancer. Recently， studies have found that methylation of RASSF1A may be a marker for molecular diagnosis of colorectal cancer. This article reviewed the function of RASSF1A and the relationship between RASSF1A and colorectal cancer.