《生命科学》 2020, 32(2): 125-138

小脑参与神经退行性病变过程的研究进展

韩　曼#，薛宪鹏#，李金泉，曾　燕*

(武汉科技大学脑科学先进技术研究院，大数据科学与工程研究院，武汉 430070)

摘　要：摘　要：小脑与大脑之间存在丰富的神经网络连接，除了精确调控运动以外，还参与调控学习记忆、情感等高级脑功能。小脑不同区域的功能障碍还与阿尔茨海默病、帕金森病、亨廷顿病、额颞叶痴呆和肌萎缩侧索硬化等神经退行性疾病特定临床症状发生之间相互关联。本文综述了小脑调控高级脑功能，以及小脑病变在几种神经退行性疾病的病理特征和临床症状发生方面的研究进展，以期为认识小脑神经退行性病变与高级脑功能受损之间的关系提供资料。

The advanced progress in understanding the cognitive function of the cerebellum and the relationship between cerebellum and neurodegenerative disorders    

HAN Man#， XUE Xian-Peng #， LI Jin-Quan， ZENG Yan*
    

(Brain Research and Advanced Technology Institute， Big Data Science and Engineering Research Institute， Wuhan University of Science and Technology， Wuhan 430070， China)

Abstract: Abstract: The cerebellum has a well-established role in controlling motor functions such as coordination， balance， posture， and skilled learning. There is mounting evidence that it might also play a critical role in non-motor functions such as cognition and emotion. It is therefore not surprising that cerebellar deficits are associated with a wide array of neurodegenerative disorders such as Alzheimer’s disease， Parkinson’s disease， Huntington’s disease， frontotemporal dementia and amyotrophic lateral sclerosis. While cerebellar neurodegeneration commonly manifest with alterations to motor function， it is now well established that the cerebellum governs non-motor function through regulation of widespread cortical and subcortical brain regions. It is thus of great clinical significance to understand the higher functions of the cerebellum. This review discusses the advance in recognition of cerebellum’s involvement in high-level cognitive/emotional functions， and characterizes cerebellar pathological changes accompanying neurodegenerative disorders.