《生命科学》 2019, 31(11): 1200-1205

甲基苯丙胺与HIV-Tat蛋白协同损伤血脑屏障的研究进展

黄　俭1，何永旺1，李　娟2，杨根梦1，许　悦1，李媛媛1，刘　柳1，曾晓锋1*，李　桢1*

(1 昆明医科大学法医学院，昆明 650500；2 昆明医科大学基础医学院，昆明 650500)

摘　要：摘　要：血脑屏障(blood brain barrier， BBB) 是维持中枢神经系统(central nervous system， CNS) 内外环境稳定的结构，在保护CNS 免受外界危险因素刺激中发挥着重要作用。甲基苯丙胺(methamphetamine， METH)滥用对人类免疫缺陷病毒(human immunodeficiency virus， HIV) 感染者的BBB 具有协同损害作用，极大提高了艾滋病相关神经认知障碍(HIV-associated neurocognitive disorders， HAND) 及艾滋病痴呆(HIV-associated dementia， HAD) 的发生率。现将对METH 与HIV-Tat 蛋白损伤BBB 的研究进展进行综述，旨在为进一步研究两者协同损伤BBB 提供参考，并为相关治疗药物的研发提供依据。

Research progress in synergistic damage of blood brain barrier induced by methamphetamine and HIV-Tat protein

HUANG Jian1， HE Yong-Wang1， LI Juan2， YANG Gen-Meng1， XU Yue1， LI Yuan-Yuan1， LIU Liu1， ZENG Xiao-Feng1*， LI Zhen1*

(1 School of Forensic Medicine， Kunming Medical University， Kunming 650500， China; 2 School of Basic Medicine， Kunming Medical University， Kunming 650500， China)

Abstract: Abstract: The blood brain barrier (BBB) is a structure for maintaining the stability of the internal and external environment of the central nervous system (CNS). It plays an important role in protecting the CNS from the stimulation of external risk factors. Methamphetamine (METH) abuse has synergistic damage effects on BBB of human immunodeficiency virus (HIV) infected people， greatly increasing the incidence of HIV-associated neurocognitive disorders (HAND) and HIV-associated dementia (HAD). Therefore， the research progress of the damage of BBB by METH and HIV-Tat protein was summarized in this paper， so as to provide reference for the further study of the synergic damage of BBB by METH and HIV-Tat protein， and provide basis for the research of related therapeutic drugs.