《生命科学》 2019, 31(11): 1192-1199

CD36在炎症反应和脂质代谢中的作用

杨晓茹1，陈宇浩1，2，郝慧芳1*

(1 内蒙古大学生命科学学院，呼和浩特 010070；2 集宁师范学院生命科学学院，集宁012000)

摘　要：摘　要：白细胞分化抗原36 (cluster of differentiation 36， CD36) 是一种高度糖基化的单链跨膜蛋白，属B型清道夫受体。其功能较为广泛，不仅可以识别“异己”成分，诱发免疫应答，还参与多种生理、病理过程。CD36 作为膜受体与其他膜蛋白和胞质蛋白组成不同的信号通路。CD36是TRL4的辅助受体，可识别病原体相关分子模式，级联NF-κB 信号通路，在天然免疫过程发挥作用；作为修饰脂蛋白受体，级联MAPK 通路，诱发无菌性炎症及脂代谢紊乱，并参与动脉粥样硬化病变；作为外源长链脂肪酸受体，通过AMPK/mTOR信号通路在能量代谢及脂质蓄积过程中发挥调控作用。该文综述了CD36 的分子特征及其偶联相关信号通路在天然免疫和脂代谢等方面的作用与机制，展示CD36 的多功能特点，为相关生物医学研究提供依据。

The role of CD36 in inflammatory response and lipid metabolism

YANG Xiao-Ru1， CHEN Yu-Hao1，2， HAO Hui-Fang1*

(1 School of Life Sciences， Inner Mongolia University， Hohhot 010070， China; 2 College of Life Sciences， Jining Normal University， Jining 012000， China)

Abstract: Abstract: The cluster of differentiation 36 (CD36) is a highly glycosylated single-chain transmembrane protein belonging to the B type scavenger receptor. The CD36 not only identifies the “exotic”component to cause immune response， but also regulates a variety of physiological and pathological processes. As a TLR4 co-receptor， CD36 recognizes pathogen-associated molecular patterns to activate NF-κB signaling pathway， which regulates the natural immune process. As a modified lipoprotein receptor， CD36 induces aseptic inflammation and lipid metabolism disorders to promote the development of atherosclerotic lesions through MAPK pathway. As an exogenous longchain fatty acid receptor， CD36 regulates the energy metabolism and lipid accumulation through the AMPK/mTOR signaling pathway. In this paper， we reviewed the molecular characteristics of CD36 and its role and mechanism in natural immunity and lipid metabolism， providing a basis for better application in biomedicine.