《生命科学》 2019, 31(11): 1173-1178

转录因子Pdx1在胰腺发育及糖尿病中的研究进展

闫承志

(西华师范大学生命科学学院，西南野生动植物资源保护教育部重点实验室，南充 637000)

摘　要：摘　要：Pdx1 (pancreatic and duodenal homeobox 1) 是一种同源框转录因子，在胰腺发育及β 细胞功能维持中起重要调控作用。研究发现，Pdx1 基因纯合缺失会导致胰腺发育不全；在β 细胞成熟与分化过程中，Pdx1 通过协同其他因子或以顺式调控的方式参与调节；此外，Pdx1 可以直接与胰岛素启动子结合，调节胰岛素合成与分泌。近来针对Pdx1 的研究表明，它在β 细胞重塑、基因编辑及药物开发等方面具有重要作用。现就Pdx1 在胰腺发育中的作用机制及其在糖尿病治疗中的进展进行综述。

The role of Pdx1 in pancreas development and diabetes

YAN Cheng-Zhi

(Key Laboratory of Southwest China Wildlife Resource Conservation of the Ministry of Education， College of Life Science， China West Normal University， Nanchong 637000， China)

Abstract: Abstract: Pdx1 (pancreatic and duodenal homeobox 1) is one of the homeodomain transcription factors， and it is essential in pancreas development and islet β-cell function. It has been reported that homozygous deficiency of Pdx1 in mice leads to pancreatic agenesis. Pdx1 can also regulate β-cell maturation and differentiation by cooperating with other factors or cis-acting. In addition， Pdx1 increases insulin secretion through directly binding to and activating insulin promoter. In recent studies， Pdx1 is proved to play an important role in generation of β-like cells， gene editing and drug development. Therefore， this article mainly reviews the role and molecular mechanisms of Pdx1 in pancreas development and diabetes.